DERMABOND cyanoacrylate tissue

OPHTHALMIC GLUE Cyanoacrylate tissue adhesive (isodent, dermabond, msTOACRYL), while not FDA approved for the eye, is widely used in the management of corneal ulcerations and... 

Spauwen PH, de Laat WA, Hartman EH. Octyl-2-cyanoacrylate tissue glue (Dermabond ) versus Monocryl 6x0 sutures in lip closure. Cleft Palate Craniofac J. 2006 43 625-627. 

At present there is only one commercially available tissue adhesive with approved on-label indications for skin closure. 2-Octyl-cyanoacrylate (Dermabond, Ethicon, Inc., Somerville, NJ) is presently indicated for skin closure in wounds which are not under extreme tension. This tissue adhesive is approved for topical skin application only. It is not indicated for internal use. The material is useful in closing traumatic skin lacerations [4,5] after wounds have been thoroughly cleaned as well as for minimally invasive surgical incisions and even larger surgical incisions in elective cases. The cyanoacrylate is applied while the skin... 

Ethicon, Inc., (Somerville, NJ) vendors Dermabond Topical Skin Adhesive for closing surface or skin type wounds. This material is not intended for internal use. Closure Medical Corporation manufactures the actual adhesive. Ethicon, Inc. is a Johnson Johnson company. Dermabond is chemically 2-octylcyanoacrylate and it cures on contact with water, ethanol and others (i.e., addition polymerization and catalysis by weak bases). For internal tissues, the excessive moisture can overcure cyanoacrylate by saturating its surface with moisture, cause disbondment from the substrate, and render it useless as an adhesive. The cured polymer possesses a hard and brittle consistency. 

Cyanoacrylate Adhesives n alkyl -2-cyanocrylates polymerize rapidly via anionic initiation in the presence of weak bases (water, alcohol) at ambient temperatures highly exothermic reaction yielding brittle polymers very useful for quickly setting anaerobic adhesives also useful for suture less topical tissue adhesives (e.g., Dermabond ) and industrial grades are commonly known as super glue. ... 

Dermabond (2-octylcyanoacrylate by Ethicon, a Johnson Johnson Company), the latest in cyanoacrylate technology, has less toxicity and almost four times the strength of n-butyl-2-cyanoacrylate. Special plasticizers have been added to the formula to provide flexibility. It is marketed to replace sutures that are 5-0 or smaller in diameter for incision or laceration repair. Patients, especially children, readily accept the idea of being glued over traditional methods of repair [38]. This adhesive reaches maximum bonding strength within 2.5 min and is equivalent in strength to healed tissue at 7 days post-repair [38]. 

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