Dequalinium chloride

C, H2 l2 16355-92-3) see Dequalinium chloride 5-[[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]metbyl]-5-metbyl-2,4-imidazolidinedione (C,jH,6l2Ni04 J/65-0J-9) see Etiroxate... 

Figure 1 Chemical structures of commonly used typical mitochondriotropic molecules (A) rhodamine 123 (B) methyltriphenylphosphonium (Q dequalinium chloride.

Dequalinium chloride (10 mM final) and paclitaxel (10 mM final) were dissolved in methanol in a round-bottom flask followed by removing the organic solvent with a rotary evaporator. After adding 5 mM HEPES, pH 7.4, the suspension was sonicated with a probe sonicator until a clear opaque solution of DQAsomes with encapsulated paclitaxel was obtained (usually for about one hour). To remove undissolved material, the preparation was centrifuged for 10 minutes at 3000 rpm. 

The solubility of paclitaxel in water at 25°C at pH 7.4 is 0.172mg/L (0.2 pM), extremely low, making any separation procedure of nonencapsulated paclitaxel from DQAsomes unnecessary i.e., in an aqueous environment, only paclitaxel encapsulated in DQAsomes would stay in colloidal solution. However, for control, a paclitaxel suspension was probe sonicated under identical conditions used for the encapsulation of paclitaxel into DQAsomes, but in the complete absence of dequalinium chloride. As expected, upon centrifugation, no paclitaxel was detectable in the supernatant using ultraviolet (UV) spectroscopy at 230 nm. 

Chemical Name l,l -Decamethylenebis(4-aminoquinaldinium chloride) Common Name Dechalinium chloride, Dequalinium chloride Structural Formula ... 

Dose. Lozenges containing 250 pg of dequalinium chloride are available. 

Zomepirac Sodium Dequalinium Chloride Conessine Hydrobromide... 

Ambutonium Bromide Benzethonium Chloride Benzilonium Bromide Chlorproguanil Dequalinium Chloride Dofamium Chloride Glycopyrronium Bromide Guanoclor... 

Depo-Estradiol Cypionate, 831 Depo-Medrone, 772 Depo-Provera, 726 Depostat, 637 Deprenaline, 968 Deprenil, 968 Deprenyl, 968 Deprex, 346, 529 Deprol, 375, 733 Depronal, 522 Depronal SA, 522 Deptropine, 514 Deptropine citrate, 514 Dequadin, 514 Dequalinium acetate, 515 Dequalinium chloride, 514 Dequavagyn, 514 Derbac, 429, 717 Derivative formation, in gas chromatography, 188 in high pressure liquid chro matography, 210 Derivative spectrophotometry, 230 Dermalar, 625 Dermo 6, 949... 

Dequadin dequalinium chloride, dequalinium chloride [ban. inn] (natrallnlum chloride Dequadin Labosept ) is a bisquaternary quinolinium ANTISEPTIC, with some ANTIFUNGAL and ANTIBACTERIAL activity. Clinically, it may be used topically, commonly as throat lozenges. 

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