Depolarization-induced suppression of inhibition

Kreitzer AC, Regehr WG (2001b) Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J Neurosci 21 RC174... 

Presynaptic G-protein coupled receptors for a large number of neurotransmitters, both autoreceptors and receptors for extrinsic signals, suppress Ca2+-channel gating in response to an action potential. This mechanism of action appears to be the dominant mechanism involved in short-term plasticity mediated by presynaptic receptors. A typical example is depolarization-induced suppression of inhibition (DSI), which is the short-term suppression of presynaptic GABA-release induced by the depolarization of the postsynaptic cell (Diana and Marty, 2004). DSI is caused when the postsynaptic depolarization causes the release of endocannabinoids from the postsynaptic cell, and the endocannabinoids then bind to presynaptic CB1 receptors whose activation suppresses presynaptic Ca2+-channels. Like many other forms of presynaptic suppression mediated by activation of presynaptic receptors, this effect is short-lasting (in the millisecond range). The precise mechanisms by which Ca2+-channels are suppressed appear to vary between receptors, but the outcome is always a very effective short-term decrease in synaptic signaling. 

Diana MA, Marty A (2003) Characterization of depolarization-induced suppression of inhibition using paired interneuron-Purkinje cell recordings. J Neurosci 23 5906-18... 

Morishita W, Kirov SA, Alger BE (1998) Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1. 

Wagner JJ, Alger BE (1996) Increased neuronal excitability during depolarization-induced suppression of inhibition in rat hippocampus. J Physiol 495(1) 107-12... 

Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M (2002) The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J Neurosci 22(5) 1690-7... 

Hampson RE, Zhuang SY, Weiner JL, Deadwyler SA (2003) Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus. J Neurophysiol 90 55-64... 

Diana MA, Marty A (2004) Endocannabinoid-mediated short-term synaptic plasticity depolarization-induced suppression of inhibition (DSl) and depolarization-induced suppression of excitation (DSE). Br J Pharmacol 142 9-19... 

Lenz, R.A., Wagner, J.J., and Alger, B.E. (1998) N- and L-type calcium channel involvement in depolarization-induced suppression of inhibition in rat hippocampal CAl cells. Journal of Physiology 512 61-73. 

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