2-deoxyribose hydroxyl radical-mediated oxidation

Hydroxyl Radical-Mediated 2-Deoxyribose Oxidation Reactions 67... 

The DNA is susceptible to changes that would lead to mutations. For example, DNA bases are damaged by an enconnter with free radicals or environmental chemicals. Hydroxyl radical mediated damage on sugars (deoxyribose) is a part of the known C 4 mechanism and leads to strand breaks. Oxidative damage of bases, usually leads to adduct formation, as exemplified above with 8-hydroxydesoxyguanosine. 

Oxidants such as hydroxyl radical or peroxynitrite also react with the 2 -deoxyribose scaffold of DNA. Each hydrogen on the 2 -deoxyribose ring is subject to free radical-mediated abstraction and subsequent diffusion-limited reaction with molecular oxygen. Each site of peroxidation leads to a separate and overlapping array of products. Following hydrogen abstraction on 2 -deoxyribose by reactive oxygen... 

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