Hydroxyl Radical-Mediated 2-Deoxyribose Oxidation Reactions

Hydroxyl Radical-Mediated 2-Deoxyribose Oxidation Reactions 

The main oxidation reactions of the 2-deoxyribose of DNA are mediated by OH that are able to abstract hydrogen atoms from most of the positions with the exception of the methylene group at C2, which is a poorly reactive site [12, 14, 112], An abundant literature is available on the degradation pathways that are derived from the reactions of osidic carbon-centered radicals and that lead in most cases to the formation of strand breaks [12, 14, 112], However, there is one major exception that concerns the chemical reactions of the CT radical that is the precursor of 2-deoxyribonolactone [113]. Here, emphasis is placed on reactions of C4 and C5 radicals that may lead to the formation of base modifications either as tandem lesions or clustered damage. 

---

Hydroxyl Radical-Mediated 2-Deoxyribose Oxidation Reactions 67... 

Oxidants such as hydroxyl radical or peroxynitrite also react with the 2 -deoxyribose scaffold of DNA. Each hydrogen on the 2 -deoxyribose ring is subject to free radical-mediated abstraction and subsequent diffusion-limited reaction with molecular oxygen. Each site of peroxidation leads to a separate and overlapping array of products. Following hydrogen abstraction on 2 -deoxyribose by reactive oxygen... 

---