Deoxyguanosine phosphates

Lu, C. Lin, W. Wang, W. Han, Z. Yao, S. Lin, N. (2000). Riboflavin-(VB2) photosensitized oxidation of 2 -deoxyguanosine-5 -mono-phosphate (dGMP) in aqueous solution A transient intermediates study. Physical Chemistry Chemical Physics, Vol.2, 0anuary 2000), pp.329-334, ISSN 1463-9076. 

The coordinating properties of a zinc 2,2 -bipyridyl unit with adenosine 5 -triphosphate and cytidine 5 -triphosphate were studied in aqueous solution. The binding of zinc to both phosphate and ATP nitrogen donor was observed with the potential for displacement of the ATP nitrogen donor by hydroxide.426 The interaction of zinc with the phosphate groups in a platinum(II) bound 2 -deoxyguanosine 5 -monophosphate has been studied in aqueous solution, with little difference noted in the coordinating properties of the phosphate residue or backbone relative to the free nucleobase.427... 

The structures of the N-substitution products are reminiscent of the C-8 adduct that is the major product of the reaction of 2-fluorenyl-, 4-biphe-nylyl- and other N-arylhydroxylamine and hydroxamic acid esters with 2 -deoxyguanosine, (d-G) 2 deoxyguanosine-5 -phosphate (d-GMP), guano-sine, (G) or DNA in an aqueous environment." The mechanism of this reaction was not seriously investigated for many years because of the mistaken impression that the reaction was inefficient and could not compete with... 

Deoxyguanosine 5 -phosphate Guanine + deoxyribose + phosphate Nucleoside is 2 -deoxyguanosine, composed of guanine and deoxyribose... 

Andersen, R.B. Neuhard, J. Deoxynucleoside kinases encoded by the yaaC and yaaF genes of Bacillus subtilis. Substrate specificity and kinetic analysis of deoxyguanosine kinase with UTP as the preferred phosphate donor. J. Biol. Chem., 276, 5518-5524 (2001)... 

ATP -I- 2 -deoxynucleoside = ADP + 2 -deoxynucleoside 5 -phosphate (<1>, compulsory ordered steady-state reaction mechanism with formation of a ternary complex with the phosphate donor and acceptor [2] the enzyme from embryonic cells of Drosophila melanogaster differs from other deoxynucleoside kinases [EC 2.7.1.76 (deoxyadenosine kinase) and EC 2.7.1.113 (deoxyguanosine kinase)] in its broad specificity for all four common deoxynucleosides)... 

Svoboda P, Harms-Ringdahl M (2002) Kinetics of phosphate-mediated oxidation of ferrous ion and formation of 8-oxo-2 -deoxyguanosine in solutions of free 2 -deoxyguanaosine and calf thymus DNA. Biochim Biophys Acta 1571 45-54... 

Electrochemical oxidation of some catecholamines such as dopamine, L-dopa, and methyldopa has been studied using cyclic voltammetry. The catecholamines undergo intramolecular cyclization to form the corresponding o-quinone derivatives. The significant differences in the electrochemical behaviour of the catecholamines have been attributed to the effects of the side-chain carboxyl group.253 Electron-transfer reactions of 2,-deoxyguanosine-5,-monophosphate (dGMP) in phosphate buffers by cyclic... 

The group of Ludlum developed a high-performance liquid chromatography (HPLC) method for the analysis of N7-HETE-Gua (9) and also a 32P-postlabeling method for N7-HETE-deoxyguanosine 5 -phosphate (10). 

A close look at this reaction reveals that in the opposite direction, the reaction is of the phosphorolysis type. For this reason, the enzymes catalyzing the reaction with ribose-l-phosphate are called phosphorylases, and they also participate in nucleic acid degradation pathways. Purine nucleoside phosphorylases thus convert hypoxanthine and guanine to either inosine and guanosine if ribose-l-phosphate is the substrate or to deoxyinosine and deoxyguanosine if deoxyribose-1-phosphate is the substrate. Uridine phosphorylase converts uracil to uridine in the presence of ribose-l-phosphate, and thymidine is formed from thymine and deoxyribose-l-phosphate through the action of thymidine phosphorylase. 

Which of the following compounds is different from the others (a) GMP, (b) deoxyguanosine monophosphate, (c) guanylic acid, (d) guanosine 5 -phosphate ... 

Kornberg s work on the biosynthesis of deoxyribonucleic acid has shown that enzymes in Escherichia coli extracts catalyze the formation of the 5-triphosphates of 2-deoxyadenosine, 2-deoxyguanosine, 2-deoxycyti-dine, and thymidine from the corresponding monophosphates in the presence of adenosine 5-triphosphate, but fail to catalyze phosphorylation of deoxyuridine 5-phosphate this finding could explain why uracil is not a constituent of deoxyribonucleic acid. 

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