Hydroxamic acid esters

The mechanism of Scheme 34 quantitatively explains the yields of rearrangement, solvent-derived and N3-derived products of hydrolysis of hydroxylamine or hydroxamic acid esters that yield selective nitrenium ions (log 5 One of the characteristics of these hydrolysis reactions is the... 

The structures of the N-substitution products are reminiscent of the C-8 adduct that is the major product of the reaction of 2-fluorenyl-, 4-biphe-nylyl- and other N-arylhydroxylamine and hydroxamic acid esters with 2 -deoxyguanosine, (d-G) 2 deoxyguanosine-5 -phosphate (d-GMP), guano-sine, (G) or DNA in an aqueous environment." The mechanism of this reaction was not seriously investigated for many years because of the mistaken impression that the reaction was inefficient and could not compete with... 

Differently cross-linked poly(methyl methacrylate) (PMMA) (137) has been employed for the synthesis of supported hydroxamic acids 138 after treatment with hydroxylamine, and reacted with acyl chlorides in the presence of pyridine to give the supported hydroxamic acid esters 139, which are suitable as solid acyl transfer reagents when reacting with alkyl and aryl amines (Scheme 7.42) [143]. 

The reaction of hydroxamoyl chlorides with the pyridine-S03 complex affords the salts of the hydroxamic acid ester chlorides XL ( ). 

Aminohydroperoxides Aminoxycarbonyl Hydroxamic acid esters Hydroximic acids Iminocarbonic acid esters... 

Sodium hydride 1-Sulfonyloxy-l-alkoximes from hydroxamic acid esters... 

Dialkoxyammonium salts Hydroxamic acid esters Hydroximic acids (esters) Iminocarbonic acid esters Nitronic — (O-Alkyl-... 

Grigg and co-workers recently demonstrated a cascade consisting of an intramolecular carbopalladation, carbonylation, and nncleophilic attack by an immobilized hydroxamic acid ester (Scheme 28). ... 

Hydroxamic acid esters from carboxylic acids and alkoxylamines... 

Ring closures with hydroxamic acid esters 4-Alkoxy-lH-l,4-benzodiazepine-2,5(3H,4H)-diones... 

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