Dendritic polyamine

Sequential hydroformylation/reductive amination of dendritic perallylated polyglycerols with various amines in a one-pot procedure to give dendritic polyamines in high yields (73-99%). Furthermore, the use of protected amines provides reactive core-shell-type architectures after deprotection. These soluble but membrane filterable multifunctional dendritic polyamines are of high interest as reagents in synthesis or as supports in homogeneous catalysis as well as nonviral vectors for DNA-transfection (Scheme 18) [65]. 

Dendritic Polyamines Structural Requirements for Efficient Gene Binding. 101... 

From the structural point of view, polyamines used for gene transfection vary widely in their structures, which range between linear [24, 29-35], branched [12, 30, 32], hyperbranched, and perfect branched dendrimers [36]. In this chapter we present a general overview of the research reported so far using dendritic polyamines in gene delivery applications. Particular focus is made on hyperbranched... 

Kraemer M (2004) Dendritic polyamines simple access to new materials with defined treelike structures for application in nonviral gene delivery. ChemBioChem 5(8) 1081... 

Treatment of a dendritic polyester 5 with a dendritic polyamine 6 is perhaps the simplest example of coupling between two dissimilar cascade macromolecules.178-801 Scheme 9.2 illustrates some potential products (i.e., 7 and 8) available by this general procedure, as well as a continuation of surface amidation to afford polymeric species such as random network 9. As envisioned, it would be difficult to stop this procedure after the formation of a single amide bond, due to the close proximity of adjacent ester—amine groups. 

The bis-porphyrin forms a cleft which, after complexation with Zn(II), acts as a receptor for a,o>-diaminoalkanes. For example 1,12-diaminododecane is bound with an association coiLstant of K. = 7.0 x 10 mol L. When a first-generation dendritic polyamine bearing four terminal primary amine groups is used as a guest, two receptor molecules assemble in such a way that they encapsulate the small dendrimer molecule, as in 50 (Figure 28). This was proven by titration studies, using H NMR and UV-vis absorption spectroscopy. 

M. Suzuki and co-workers reported the preparation of hyperbranched dendritic polyamines by multibranching polymerizations of cychc carbamates (Scheme 68). 

The choice of appropriate activating group for the carboxyUc acid function of the C(o building block 1 was the key to this synthesis. Effectively, the reaction conditions for the activation step may not be strongly acid or basic, to preserve the ester functions. Furthermore, the grafting onto the dendritic polyamines requires an extremely efficient reaction to obtain the corresponding functionaUzed derivatives with good yields and to avoid the formation of defective dendrimers. The prepara-... 

III. SYNTHESIS OF HYPERBRANCHED DENDRITIC POLYAMINE BY Pd-CATALYZED RING-OPENING POLYMERIZATION OF CYCLIC CARBAMATE... 

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