Dendrimer oligosaccharide-based

R. Roy, D. Zanini, S. J. Meunier, and A. Romanowska, Syntheses and antigenic properties of sialic acid-based dendrimers, in P. Kovac, (Ed.), Synthetic Oligosaccharides Indispensable Probes for the Life Sciences, ACS Symp. Sen, 560, 1994, pp. 104-119. 

Roy R, Zanini D, Meunier SJ, Romanowska A (1994) Synthesis and antigenic properties of sialic acid based dendrimers. In Kovac P (ed) Synthetic oligosaccharides. Indispensable probes for the life sciences. ACS Symposium Series 560. American Chemical Society, Washington, p 104... 

Other interests in the area of phosphorus acids and their derivatives has centered on the following subjects synthesis of new ligands and catalysts for known reactions, synthesis of supramolecular logic gates, use of phosphates as electrophiles in palladium-catalyzed cross-coupling reactions, synthesis of phosphate based dendrimers and conjugates with oligosaccharides. 

In this paper we will focus more specifically on the third one, in which the scaffold unit is originated from monosaccharides. Compare to classical Pamam, Boltorn cores, carbohydrate units add much more 3D information coded in the chirality in almost each carbon. The diversity of such stmcture has been calculated for oligosaccharides and is veiy impressive, Laine found over 1.05 x 10 possible branched hexasaccharides starting from a basis set of 6 different sugars. Compared with a set of 6 different amino acids, there is nearly 10 times less hexapeptides Thereby the possible structures of a carbohydrate-based dendrimers are tremendous and open a large possible choice of scaffolds and thus properties. In addition, various characteristics of such dendrimer can be easily controlled such as their sizes, shapes, topologies, flexibilities and their surface properties. 

Given the success of Bertozzi s example, it is perhaps surprising that not more multivalent scaffolds based on glycosyl hydrazide chemistry have been reported. One of the few examples has been described by Liu and coworkers, who have shown that oligosaccharides can readily be displayed on modified poly(amido amine) (PAMAM) dendrimers via a hydrazide linkage. These dendrimers were shown to be readily taken up by hepatocytes in a glycan-dependent fashion [35]. Similarly, dendrimers have been used to increase the density of carbohydrate... 

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