Phosphorus acids

Haloacetyl groups have also a synthetic potential. Thus, pesticidal (alkylthio)-vinyl esters of phosphorus acid derivatives have been prepared by the introduction and subsequent displacement of two chlorine atoms in the acetyl moiety attached to the furazan ring (Scheme 69) [73GEP(0)2144393]. 

The reaction of the end OH group of the oleylamide of A-hydroxyethyl-diethylentriamine with phosphorus trichloride and water in the presence of carbon tetrachloride yielding a primary phosphorus acid ester [63], as is shown in Eq. (74), is a typical reaction of this type. 

The catalytic activity of surfactant micelles and the effect of the concentration of reagents in micelle catalysis are tested on hydrolysis of esters of phosphorus acids [25],... 

Phosphotriesterase from P. diminuta (PTE) was found to exhibit high hydrolytic activity towards various types of tetracoordinated phosphorus acid esters. Apart from the phosphonothionate 92, phosphoric acid triesters 94 (Equation 45), °" benzenephosphonic acid diester 95 (Equation 46) ° and methyl-phenylphosphinic acid ester 96 (Equation 47) were also stereoselectively hydrolysed under kinetic resolution conditions. Of course, in the case of the latter three kinds of substrates, half of the reacting ester was irreversibly lost due to the formation of achiral phosphorus acids. 

It is possible to make an acid chloride by the action of phosphorus trichloride on an acid. Three accidents have been described that involved the action of this compound on acetic, propionic and 2-furoic acids, respectively. This was explained by the formation of phosphine due to excessive heating that led to the decomposition of the phosphorus acid formed ... 

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