Delta-aminolevulinate synthase

Bishop DF, Henderson AS, Astrin KH (1990) Human delta-aminolevulinate synthase assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosome. Genomics 7 207-214... 

Cable, E.E., Cable, J.W., Bonkovsky, H.L. Depression of hepatic delta-aminolevulinate synthase by heme and metalloporphyrins relationship to inhibition of heme oxygenase. Hepatology 1993 18 119 — 127... 

Alterations in blood heme metabolism have been proposed as a possible indicator of the biological effects of hydrogen sulfide (Jappinen and Tenhunen 1990), but this does not relate to the mechanism of toxicity in humans. The activities of the enzymes of heme synthesis, i.e., delta-aminolevulinic acid synthase (ALA-S) and heme synthase (Haem-S), were examined in 21 cases of acute hydrogen sulfide toxicity in Finnish pulp mill and oil refinery workers. Subjects were exposed to hydrogen sulfide for periods ranging from approximately 1 minute to up to 3.5 hours. Hydrogen sulfide concentrations were considered to be in the range of 20-200 ppm. Several subjects lost consciousness for up to 3 minutes. 

Goering PL, BA. 1987. Metal constitution of metallothionein influences inhibition of delta-aminolevulinic acid dehydratase (porphobiligen synthase) by lead. Biochem J 245 339-345. 

EXDVXXGXPPAA Delta-aminolevulinic acid dehydratase, chloroplast precursor (porphobilinogen synthase) (ALADH) (ALAD)/ 60-94 Selaginella martensii 100% 0.05... 

Strand LJ, Swanson AL, Manning J et al. (1972) Radiochemical microassay of delta-aminolevulinic acid synthase in hepatic and erythroid tissue. Anal Biochem 47 457 170... 

The first step in the heme pathway takes place inside mitochondria and involves the enzymatic condensation of succinyl-CoA with glycine to form delta-aminolevulinic acid (ALA) via the enzyme ALA-synthase (Figure 4-1). That is... 

Weaver, V.M., B.K. Lee, A.C. Todd, K.D. Ahn, W. Shi, B.G. Jaar, K.T. Kelsey, M.E. Lustberg, E.K. Silbergeld, P.J. Parsons, J. Wen, and B.S. Schwartz. 2006. Effect modification by delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers. Environ. Res. 102(l) 61-69. 

Weaver, V.M., Schwartz, B.S., Jaar, B.G., Ahn, K.-D., Todd, A.C., Lee, S.-S., et al., 2005. Associations of uric acid with polymorphisms in the delta- aminolevulinic dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers. Environ. Health Perspect. 113, 1509—1515. 

Mitchell, R.A., Drake, J.E., Wittlin, C.A. and Rejent, T.A. (1977) Erythrocyte porphobilinogen synthase (delta-aminolevulinate dehydratase) activity a reliable and quantitative indicator of lead exposure in humans. Clin. Chem., 23, 105-111 Needleman, H.L., Gunnoe, C., Leviton, A., Reed, R., Peresie, H., Maher, C. and Barrett, P. (1979) Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N. Engl. ]. Med., 300, 689-695... 

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