DeJongh model

The DeJongh model is similar to the Lachance-Trail model 16), but includes correction for self-absorption effects. The alpha coefficients shown in Table 5 were used as starting values for the straight line regression procedure executed by the PW-1400 software package. 

Schaddelee MP, Collins SD, DeJongh J, de Boer AG, Ijzerman AP, Danhof M. Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and antinociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain. Eur J Pharmacol 2005 May 9 514(2-3) 131-40. 

Post, T. M., Freijer, J. I., Dejongh, J., Dan-hof, M. Disease system analysis basic disease progression models in degenerative disease. Pharm Res 2005, 22 1038-1049. 

Survey of Canada in Ottawa [4]. The matrix correction model used in this work was that described by DeJongh [5]... 

B. Ploeger, T. Mensinga, A. Sips, J. Meulenbelt, and J. DeJongh, Ahuman physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling. Pharm Res 17 1516-1525 (2000). 

C. A. Knibbe, K. P. Zuideveld, J. DeJongh, P. F. Kuks, L. P. Aarts, and M. Danhof, Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients a comparison between propofol 6% and propofol 1%. Clin Pharmacol Ther 72 670-684 (2002). 

Ploeger BA, Meulenbelt J, DeJongh J (2000) Physiologically based pharmacokinetic modelling of glycyrrhizic acid, a compound subject to presystemic metabolism. Toxicol Appl Pharmacol 162 177-188... 

Henry CS, DeJongh M, Best AA, Frybarger PM, Linsay B, Stevens RL (2010) High-throughput generation, optimization and analysis of genome-scale metabolic models. Nat Biotech... 

C.U.deJongh, A.H.Basson, C.Scheffer (2008), Predictive modelling of cervical disc implant wear . Journal of Biomechanics Vol. 41 pp. 3177-3183. 

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