Dehydroepiandrosterone effects

Fletcher A, Forster EA, Bill DJ, et al Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HTj receptor antagonist. Behav Brain Res 73 337-353, 1996 Fletcher PJ, Higgins GA Differential effects of ondansetron and alpha-flupenthixol on responding for conditioned reward. Psychopharmacology 134 64-72, 1997 Flood JF, Smith GE, Roberts E Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 447 269-277, 1988... 

The byproduct sitosterol was for many years quite useless due to the lack of a chemical point of attack on the side chain that would permit its removal. Extensive efforts on the part of many laboratories eventually led to the discovery of a pseudomonas microbe that efficiently effected that transformation. Fermentation of (4-1) digests the entire aliphatic side chain at 17 to afford a mixture of 17-keto products including dehydroepiandrosterone (4-2) [4]. 

Gynecomastia was occasionally observed in men when ketoconazole first became available. Ketoconazole has a marked effect on steroid concentrations, including a change in the testosterone/estradiol ratio, and this is most likely to be the basis of the gynecomastia. A lowering of testosterone serum concentrations and a reduced response of testosterone concentrations to human gonadotropin have been shown (SED-11, 573) (583). Various studies have shown suppression of testosterone, androste-nedione, and dehydroepiandrosterone, with reciprocal increases in gonadotrophins. 

Because of its effects on the pituitary/adrenal system, ketoconazole has been used in the long-term control of hypercortisolism of either pituitary or adrenal origin (SED-12, 677). In seven patients with Cushing s disease and one with an adrenal adenoma, ketoconazole 600-800 mg/day for 3-13 months produced rapid persistent clinical improvement (585). Plasma dehydroepiandrosterone sulfate concentrations and urinary 17-ketosteroid and cortisol excretion fell soon after the start of treatment, and remained normal or nearly so throughout treatment. Urinary tetrahydro-ll-deoxycortisol excretion rose... 

Deuster PA, Faraday MM, Chrousos GP, Poth MA. Effects of dehydroepiandrosterone and alprazolam on hypothalamic-pituitary responses to exercise. J Chn Endocrinol Metab 2005 90(8) 4777-83. 

Much remains unknown about melatonin s interaction with many other drugs and substances. However, it is known that melatonin does interact with, and may limit the effectiveness of, benzodiazepines, methamphetamines, dehydroepiandrosterone, magnesium, zinc, corticosteroids, and succinylcholine. People who are being treated with these drugs should not take melatonin. 

The medical use of botanicals in their natural and unprocessed form undoubtedly began when the first intelligent animals noticed that certain food plants altered particular body functions. Much information exists about the historical use and effectiveness of botanical products. Unfortunately, the quality of this information is extremely variable. One of the most complete compendiums of clinical recommendations regarding the use of botanicals is the Report of the German Commission E (a committee that sets standards for herbal medications in that country Blumenthal, 2000). Interest in the endocrine effects and possible nutritional benefits of certain purified chemicals such as dehydroepiandrosterone. melatonin, high-dose vitamins, and minerals has led to a parallel development of consumer demand for such substances. These substances, together with the botanicals, constitute a substantial source of profits for those who exploit the concept of "alternative medicine."... 

Papaverine dehydroepiandrosterone-3-monophosphate (151) had a much more rapid coronary vasodilator action on the isolated cat heart than papaverine the effect of papaverine was, however, of longer duration. Both compounds inhibited histamine bronchospasms. The spasmolytic effect of papaverine dehydroepiandrosterone-3-mono-phosphate on histamine-induced contractions of the small intestine of guinea pigs was twice as strong as that of papaverine but less toxic than papaverine. 

Fig. 19. Effect of treatment with dehydroepiandrosterone (DHEA) (10 mg, percuta-neously, once daily) or EM-800 (75 pg, orally, once daily) alone or in combination for 9 months on the incidence of dimethylbenz (a) anthracene (DMBA)-induced mammary carcinoma in the rat throughout the 279-day observation period. Data are expressed as percentage of the total number of animals in each group (Luo et al., 1997c).

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