Deep therapeutic targets

Other symptomatic therapeutic interventions are surgical procedures and deep brain simulation with three targets ventral intermediate nucleus of thalamus, the internal segment of the globus pallidus and the subthalamic nucleus. 

Aerosolized DNase (dornase) is a therapeutic protein designed for alveoli delivery to achieve local effects in the deep lung. Aerosolized DNase is formulated as a pulmonary dosage form, targeted for deep-lung delivery to reduce opportunistic infections due to the increased viscosity of mucus in the lung that affects respiratory function in patients with cystic fibrosis. 

Pulmonary deposition of an aerosol preparation is determined primarily by its size. Aerosols with a mass median aerodynamic diameter of 1-5 xm produce the best therapeutic results and are the target particle size for inhalation therapy. These small particles penetrate deep within the respiratory tract to ensure drug deposition in peripheral airways. The cross-sectional area (cm ) of the lung increases dramatically at the level of the respiratory zone therefore, the velocity of gas flow during inspiration rapidly decreases at this level. Moderate-sized particles (5-10 (xm) frequently settle out by sedimentation in larger more central airways because the velocity of gas falls rapidly in the region of the terminal bronchioles. 

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