Decoding Mechanism

Ogle, J. M. Carter, A. P. Ramakrishnan, V. Insights into the decoding mechanism from recent ribosome structures. Trends. Biochem. Sci. 2003, 28, 259-266. 

Masurekar et al. 1981). These observations established early on that the binding of small molecules to the ribosome could affect translational fidelity. Evidently, the ribosome was involved in translation beyond its catalytic activity. Over the last few decades, aminoglycosides have been instrumental in the elucidation of the decoding mechanism. 

Ogle JM, Brodersen DE, Clemons Jr WM, Tarry MJ, Carter AP, Ramakrishnan V (2001) Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science 292 897-902 Ogle JM, Murphy FV, Tarry MJ, Ramakrishnan V (2002) Selection of tRNA by the ribosome requires a transition from an open to a closed form. Cell 111 721-732 Ogle JM, Carter AP, Ramakrishnan V (2003) Insights into the decoding mechanism from recent ribosome structures. Trends Biochem Sci 28 259-266... 

A third approach for elucidating the coding of sensory qualities and quantities is to correlate responses of sensory neurons and the behavioral reactions released by the same chemical stimuli. But correlations do not prove causative relations and they cannot replace studies of the CNS and its decoding mechanisms. Such attempts will have to be based on a thorough understanding of the inputs (sensory nervous activity) and the outputs (motor programs as units of behavioral reactions) of the central nervous structures. 

D. Liu and X. Cai, Decoding Mechanisms of Crystallization Technology Underl 4ng Genetic Information Transduction, ShengmingDeHuaxue, 2013, 33, 67. 

In keeping with the minimalist design philosophy, all the aforementioned instructions are executed within a single clock cycle, thereby avoiding the need for complex instruction-decoding mechanisms and counters within the PE to keep track of its execution state. 

One might, in fact, see resistance as one side effect of the authoritarianism of a therapeutic model that assumes, a priori, that psychopathogenic mechanisms are obscure and only knowable through a process of symbol decoding by a bearded sage sitting behind us In my experience, most patients today are only too fully aware of the adverse aspects of their... 

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