DCC gene

The deleted in colorectal carcinoma (DCC) gene encodes for a membrane protein of the immunoglobulin superfamily. The exact function of DCC has yet to be elucidated. However, studies have suggested a role in axonal develop-... 

O Boyle K. The role of the Deleted Colon Cancer (DCC) gene in colorectal and gastric cancer. Cancer Invest 2003 12 484-85,... 

Allelic loss of chromosome 18q, which is located on the DCC gene, is predictive of mortality, independent of tumor differentiation, vascular invasion, and TNM stage. Five-year smvival rates decrease by 39% and 14% in patients with allelic loss of chromosome 18q and stage II or III colorectal cancer, respectively. Tumors that overexpress TS, which is responsible for converting de-oxyuridine monophosphate to deoxythymidine monophosphate, an... 

Ugai, H., H. O. Li, M. Komatsu, H. Tsutsui, J. Song, T. Shiga, E. Fearon, T. Murata, and K. K. Yokoyama. 2001. Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Biochem Biophys Res Commun 286(5) 1087-97. 

One of the first demonstrations of a specific gene that produced a phenotypic cancer-related factor came from an analysis of human colorectal tumors (Hedrick et al. 1994). A novel gene, DCC (deleted in colorectal cancer), was found located... 

Online Mendelian Inheritance in Man (OMIM) indicates that the development of colorectal carcinomas involves a dominantly acting oncogene coupled with the loss of several genes (such as DCC) that normally suppress tumorigenesis. 

Lethal CCF are modelled by the CPN sub-net shown in Figure 4. It corresponds to the substitution transition DCCJetale of the Figure 2. The firing of the transition gene dcc l allows to determine the occurrence time of the lethal shock using the function floor(exponential( omega)+0.5). A lethal CCF affects all the components (electronic boards) of the system and is always detected online. Thus, there are issued N temporized tokens with a color ph( DCC-NL ,l) (1 for detection). The next occurrence time for a new lethal CCF is calculated since the previous is realized. 

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