Daylight

Daylight Chemical Information Systems, Inc. http //www.daylight.com/ 

Products Summary Daylight provides chemoinformatics tools and databases for life sciences. Daylight s product portfolio includes DayCart, THOR database, Merlin exploratory data analysis, ACD database, MedChem database, SPRESI database, WOMBAT database, World Drug Index database. 

DayPropTalk It is an interactive interface that communicates with users or other processes to calculate molecular properties (See DayProp below). 

TautomerTalk It is also an interactive program that produces lists and 

Tautomers It is a non-interactive program that calculates tautomeric structures which may optionally include enol forms. 

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IP formats up to 35x43 cm can be handled automatically in full daylight. If an exposed cassette is inserted in the scanner the following actions are performed ... 

SMILES has seen many extensions since 1988. The present definition, with examples, can be found at http f/w m>.daylight.com/dayhtml/smiles/index.html. 

A special extension of SMILES is USMILES (sometimes described as Broad SMILES) [23-25]. This Unique SMILES of Daylight is a canonical representation of a structure. This means that the coding is independent of the internal atomic numbering and results always in the same canonical, unambiguous, and unique description of the compound, granted by an algorithm (see Section 2.5.2). 

The compact textual coding requires no graphical input and additionally permits a fast transmission. These are important advantages of using SMILES in chemical applications via the Internet and in online services. SMILES is also used for the input of structures in the Daylight Toolkit [22]. 

SMILES. smi SMILES the most widely used Unear code and file format nmm.daylight.com 20, 21... 

DayCart is a software cartridge which offers a range of operation on an Oracle database, such as complete structure, similarity, and substructure search. The software can be obtained from Daylight Chemical Information Systems, Inc. (Mission Viejo CA) URL www.daylight.com... 

Bradshaw J 1997. Introduction to Tversky Similarity Measure. At http //www.daylight.com meetings / mu g97 / Bradshaw / MUG97 / tv tversky.html. 

Several variations of the chemical method are in use. In the one described below, a freshly prepared Fehling s solution is standardised by titrating it directly against a standard solution of pure anhydrous glucose when the end-point is reached, I. e., when the cupric salt in the Fehling s solution is completely reduced to cuprous oxide, the supernatant solution becomes completely decolorised. Some difficulty is often experienced at first in determining the end-point of the reaction, but with practice accurate results can be obtained. The titrations should be performed in daylight whenever possible, unless a Special indicator is used (see under Methylene-blue, p. 463). 

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