Datura brugmansia

Flying Ointments, Datura, Brugmansia, Devil s Weed)... 

Numerous other species were alkaloid-positive Brachistus div-ersifolius, B. pringlei, Brugmansia (see Datura), Brunfelsia ameri-cana, B. australis, B. densiflora, B. grandiflora, B. jamaicense,... 

TREE DATURAS -- Datura, subgenius Brugmansia includes D. 

Ayahuasqueros often indude at least one additive toyagS infusions to enhance states of mind brought about by B. caapi, inebrians and quitensis. In Colombia, Daturas and dosely related species of Brugmansia are sometimes used they undoubtedly give this drink added kick but are dangerous. Often tobacco appears other additives are listed by Schultes and Hofmann ... 

Robins, R.J., Woolley, J.G., Ansarin, M., Eagles, J. and Goodfellow, B.J. (1994a) Phenyl-lactic acid but not tropic acid is an intermediate in the biosynthesis of tropane alkaloids in Datura and Brugmansia transformed root cultures. Planta, 194, 86-94. 

Boswell HD, Drager B, McLauchlan WR, Portseffen A, Robins DJ, Robins RJ, Walton NJ. Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura. Phytochemistry 1999 52 871-878. 

Brugmansia Candida (Datura Candida, angel s trumpet) and Brugmansia suaveolens (Datura suaveolens, angel s tears) are ornamental flowers that have been used for hallucinogenic effects. Both contain tropane alkaloids, such as hyoscine, hyoscyamine, meteloidine, and nor-hyoscine, which have anticholinergic properties. 

A final, less arduous and more poetic, description is provided by a woman, a shaman s apprentice who found the experience useful and instructive. "Huantuj" is the Ecuadorian term for a decoction made from the Brugmansia genus of tree daturas ... 

Tropane alkaloids are particularly numerous in the species of Atropa, Datura (inch Brugmansia), Duboisia and Hyoscyamus. It is noteworthy that classical alkaloids such as hyoscyamine, scopolamine, i.e. esters with tropic acid or related acids of alkamines derived from tropane, are restricted to the Solanaceae [7],... 

Bristol, M.L. etal 1969. The alkaloids of the genus Datura, section Brugmansia. Part VI. Tree Datura drugs Ekttura Candida cvs) of the Colombian Sibundoy ... 

Angel s trumpet Brugmansia arborea, Datura spp 1,3 Anticholinergic alkaloids (see p 84)... 

Hyoscyamine 6P-hydroxylase (H6H, EC 1.14.11.11) is a 2-oxoglutarate-dependent dioxygenase and is the final enzyme of the tropane alkaloid biosynthetic pathway. The H6H catalyzes the conversion of hyoscyamine into 6P-hydoxyhyoscyamine and scopolamine by two sequential reactions [24, 25]. Firstly, it catalyses the 6P-hydroxylation of hyoscyamine and secondly, the formation of the epoxy group leading to scopolamine [13]. Several works have revealed that the epoxidation activity is much lower than the hydroxylation one [11, 26]. These findings are in agreement to those reported in our laboratory about the H6H enzyme isolated from Brugmansia Candida (syn. Datura Candida) [27-29]. This South America n native plant is a natural hybrid between B. aurea and B. versicolor and a tropane alkaloids producer [30,31]. 

Datura comigera Hook. Brugmansia aurea Lageeih. sub nom. D. aurea (Lagerh.) Safe. 

A/-Methylpyrrolidinylhygrines H. albus Brugmansia Candida, Datura inoxia, D. ceratocaula [Datmeae clade] Physalis peruviana [Physaleaeclade/Physalinae subclade]... 

Hartmann et al. 1986), respectively. To date, 3a-phenylacetoxytropane was found again only in transformed root cultures of a Brugmansia Candida x aurea hybrid (Robins et al. 1990) as well as of Hyoscyamus x gyGrjfyi (lonkova et al. 1994), whereas the occurrence of 3a-cinnamoyloxytropane is confined to L pubiflora. A stereochemically not determined 3-phenylacetoxy-6,7-epoxytropane, found in the seeds of Datura ferox, has been mentioned already above (Vitale et al. 1995). 

Solandra (4), Brugmansia (3), Datura (5), Physalis (1)]. Surprisingly, 3P-acetoxytropane was identified only in a few species of the Solanoideae (H. albus, H. pusiUus, B. Candida x aurea, D. wrightii, P. peruviana). Finally, 3p-(2-methylbutyryloxy)tropane seems to be confined to D. inoxia (Witte et al. 1987). 

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