Data Paranasal sinuses

An increased incidence of cancer of the paranasal sinuses was observed in workers at factories where isopropanol was manufactured by the strong-acid process. The risk for laryngeal cancer may also have been elevated in these workers. It is unclear whether the cancer risk was due to the presence of diisopropyl sulfate, which is an intermediate in the process, to isopropyl oils, which are formed as by-products, or to other factors, such as sulfuric acid. Epidemiological data concerning the manufacture of isopropanol by the weak-acid process are insufficient for an evaluation of carcinogenicity (lARC, 1987). 

Selected Case-Control Studies. Luce et al. (1993b) attempted to detennine whether occupational exposure to fonnaldehyde was associated with an increased risk of sinonasal cancer in humans. Case subjects were patients with primary malignancies of the nasal and paranasal sinuses. Odds ratios for squamous cell carcinomas in formaldehyde-exposed workers, when adjusted for wood dust and glue exposure, were not significantly elevated. The odds ratio for adenocarcinomas was confounded by the frequent co-exposure to wood dust, a known carcinogen. However, in those exposed to wood dust, an increased odds ratio was noted in those also exposed to formaldehyde. The authors concluded that the data did not support an increased risk of nasal cancers due to formaldehyde alone. 

Carrascosa P, Capunay C, Vembar M, Ciancibello L, Car-rascosa J (2005) Multislice CT virtual angioscopy of the abdomen. Abdom Imaging 30 249-258 Davis CP, Ladd ME, Romanowski BJ, Wildermuth S, Knop-lioch JF, Debatin JF (1996) Human aorta preliminary results with virtual endoscopy based on three-dimensional MR imaging data sets. Radiology 199 37-40 De Nicola M, Salvolini L, Salvolini U (1997) Virtual endoscopy of nasal cavity and paranasal sinuses. Eur J Radiol 24 175-180... 

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