Ranitidine Darunavir

Proton pump inhibitors (marked effect) and H2-receptor antagonists (modest effect) reduce atazanavir levels. Other drugs that increase gastric pH are also predicted to reduce plasma levels of atazanavir. Fosamprenavir may be similarly affected (moderate effects seen with ranitidine), although antacids and esomeprazole had little effect in one study. Omeprazole decreases indinavir levels and an antacid modestly decreased tipranavir levels. Neither ranitidine nor omeprazole had any effect on darunavir/ritonavir or lopinavir/ritonavir levels. In contrast, cimetidine, ranitidine and omeprazole have been shown to increase saquinavir levels. 

In a crossover study in 16 healthy subjects, neither omeprazole 20 mg daily nor ranitidine 150 mg twice daily had a significant effect on the AUC or minimum level of darunavir after darunavir/ritonavir 400/100 mg was given twice daily for 5 days. ... 

Omeprazole and ranitidine do not appear to alter the pharmacokinetics of darunavir/ritonavir or lopinavir/ritonavir. 

Sekar VJ, Lefebvre E, De Paepe E, De Marez T, De Pauw M, Parys W, Hoetehnans RM. Pharmacokinetic interaction between darunavir boosted with ritonavir and omeprazole or ranitidine in human immunodeficiency virus-negative healthy volunteers. Antimicrob Agents Chemodter (p.007) 51, 958-61. 

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See also in sourсe #XX -- [ ]

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