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Darifenacin

B. Kaye, W. J. Heixon, P. V. Macrae, S. Robinson, D. A. Stopher, R. E. Venn and W. Wild, Rapid, solid phase exti action tecnique for the liigh-tliroughput assay of darifenacin in human plasma . Aim/. Chem. 68 1658-1660(1996). [Pg.296]

Subtype-preferring antagonists (examples)3 Pirenzepine Tripitramine Darifenacin PD102807 C... [Pg.795]

Details regarding the pharmacokinetics, contraindica-tions/precautions, and dosing of the five recommended agents (oxybutynin, tolterodine, trospium chloride, solifenacin, and darifenacin) are illustrated in Table 50-3.7 12,14 16 A current clinical controversy is which of these agents should be considered first-line in UUI, and in the case of oxybutynin and... [Pg.809]

Parameter Oxybutynin Tolterodine Trospium chloride Solifenacin Darifenacin... [Pg.810]

Guay DRP. Drug forecast Darifenacin another investigational anticholinergic for overactive bladder. Consult Pharm 2005 20 424-431. [Pg.818]

Overactive bladder Anticholinergic agentyantispas-modics Oxybulynin TDS (5.9 mg/day apply one patch twice weekly), tolterodine IR (1-2 mg twice daily), tolterodine LA (2-4 mg daily), trospium chloride (20 mg once or twice daily), solifenacin (5-10 mg daily), darifenacin (7.5-15 mg daily) Anticholinergics are first-line drug therapy (oxybulynin or tolterodine is preferred). [Pg.960]

Drug interactions are possible if CYP450 inhibitors are given with solifenacin succinate (metabolized by 3A4 isoenzyme) or darifenacin (metabolized by 2D6 and 3A4 isoenzymes). [Pg.962]

Hepatic function impairment- For patients with moderate hepatic impairment, do not exceed a daily dose of darifenacin 7.5 mg. Darifenacin is not recommended for use in patients with severe hepatic impairment. [Pg.668]

Pharmacology Darifenacin is a competitive muscarinic receptor antagonist. [Pg.668]

Distribution - Darifenacin is approximately 98% bound to plasma proteins. [Pg.668]

Metabolism - Darifenacin is extensively metabolized by the liver by cytochrome P-450 enzymes CYP2D6 and CYP3A4. [Pg.668]

Excretion - Following administration of an oral dose approximately 60% was recovered in the urine and 40% in the feces. The elimination half-life of darifenacin following chronic dosing is approximately 13 to 19 hr. [Pg.668]

Lactation It is not known whether darifenacin is excreted into human milk. Use caution before administering to a breastfeeding woman. [Pg.669]

Drugs that may interact with darifenacin include moderate and potent CYP3A4 inhibitors, anticholinergic drugs, CYP2D6 substrates, and digoxin. [Pg.669]

Bethanechol (Urecholine, Duvoid, othCTs) Darifenacin (Enablex) Dimethyl Sulfoxide [DMSO] (Rimso-50) Flavoxate (Urispas) Hyoscyamine (Anaspaz, Cystospaz, Levsin, others)... [Pg.57]

Lipton RB. Assessment of cognitive function of the elderly population effects of darifenacin. J Urol 2005 i73 493. [Pg.330]

Antagonists Pirenzepine, telenzepine, dicyclomine,2 trihexyphenidyl3 Gallamine,1 methoctramine, AF-DX 1164 4-DAMP, darifenacin, solifenacin, oxybutynin, tolterodine... [Pg.155]

Darifenacin, solifenacin, and tolterodine Tertiary amines with somewhat greater selectivity for M3 receptors ... [Pg.167]

Substrates CYP3A Anticholinergics Darifenacin, oxybutynin, solifenacin, tolterodine Benzodiazepines Alprazolam, midazolam, triazolam Ca channel blockers Diltiazem, felodipine, nimodip-ine, nifedipine, nisoldipine, verapamil... [Pg.355]

See other pages where Darifenacin is mentioned: [Pg.795]    [Pg.809]    [Pg.586]    [Pg.621]    [Pg.962]    [Pg.587]    [Pg.623]    [Pg.284]    [Pg.667]    [Pg.126]    [Pg.126]    [Pg.355]    [Pg.329]    [Pg.330]    [Pg.924]    [Pg.924]    [Pg.255]    [Pg.682]    [Pg.155]    [Pg.162]    [Pg.162]    [Pg.167]    [Pg.126]    [Pg.126]   
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See also in sourсe #XX -- [ Pg.329 ]

See also in sourсe #XX -- [ Pg.75 ]

See also in sourсe #XX -- [ Pg.186 ]

See also in sourсe #XX -- [ Pg.126 ]

See also in sourсe #XX -- [ Pg.381 , Pg.383 ]



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