Dapsone polymorphism

Commonly used drugs (other than isoniazid) affected by NAT2 polymorphism were procainamide, hydralazine, dapsone, and sulfonamides with an increase of side effects in all cases. A selective substrate of NATl is -aminosalicylic acid (PAS), but its genetic variation was never clinically important (52). Because of such lack of importance, more attention is often paid to the fact that various industrial chemicals with carcinogenic potential, and mutagenic heterocyclic amines, are substrates of both N-acetyltransferases (53). The presence or absence of these transferases will determine some incidences of cancer (54). Attempts have been made to ascribe cancer incidences in different populations to acetyltransferase differences (55). 

Kuhnert-Brandstatter, M. and Moser, I. (1979). On the polymorphism of dapsone and ethambutol dihydrochloride. Mikrochim. Acta I, 125-36. [255]... 

Dapsone-induced methemoglobinemia reportedly relapsed 10 days after drug withdrawal in a 25-year-old woman with systemic lupus erythematosus [10 ]. The authors suggested, without evidence, that the prolonged action of dapsone may have been due to a polymorphism of the CYP2E1 gene. 

Recently, Peters et al. (1970b) have reported that diaminodiphen-ylsulfone (dapsone) may also be polymorphically acetylated by the same... 

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