Dapsone antibacterial activity

HHLocher, H Schlunegger, PG Harman, P Angern, RL Then. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother 40 1376-1381, 1996. 

It may also have ANTIPSYCHOTIC activity, dapiprazole hydrochloride dapiprazole. dapitant [inn] (RPR 100893) is a substituted isoindole, a TACHYKININ RECEPTOR ANTAGONIST, selective for the NK,-receptor subtype. It has potential as an ANTIMIGRAINE AGENT, dapsone [ban, inn, usan] is a sulphone with actions similar to SULPHONAMIDES and with ANTIBACTERIAL activity. It can be used as an antileprotic and for infective dermatitis herpetiformis. and is being investigated for the treatment and prevention of Pneumocystis carinii pneumonia (e.g. in AIDS), daptomycin [ban, inn, usan] is an (aminoglycoside) antibiotic. It has antibacterial properties. 

Several sulfoxides and sulfones are biologically active examples include diaryl sulfones, e.g. dapson (89) (Figure 3). This is an antibacterial agent because it acts as a PABA antagonist like the sulfonamide drugs (see Chapter 11, p. 223). Other diaryl sulfones, e.g. tetradifon (90), are used as acaricides to control spider mites on plants. 

It is important to note that many non-sulfonamides are known that can compete with j AB (/ -aminobenzoic acid). The most used of these is dapsone 9.17), 4,4 -di(aminophenyl)sulfone, the sheet anchor of all leprosy therapy. Others contain no sulfur atom, but have the requisite steric and electronic resemblance to pAR. For example, the insertion of a chlorine atom into either the 2- or the 3-position of pAR makes an active anti-pAB substance (Wyss, Rubin and Strandskov, 1943). Diaminobenzil 2.15) is several times more active against bacteria than sulfanilamide, and is reversed by / AB (Kuhn, Weygand and Moller, 1943). Again,/ -aminobenzenearsonic acid, atoxyl 6.2) has a typical sulfanilamide-like action (Albert, Falk and Rubbo, 1944). Although, in general, arsonic acids are not antibacterial, atoxyl forms an exception because it resembles pAR sufficiently, sterically and electronically, to compete with it. 

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