4-Aminobenzenearsonic acid

Aminobenzenearsonic Acid. Same as Amino-phenyl arsonic Acid... 

SYNS p-AMINOBENZENEARSONIC ACID 4-AMINOBENZENEARSONIC ACID AMINO-PHENYLARSINE ACID p-AMINOPHENYLARSINE ACID p-AMINOPHENYLARSINIC ACID 4-AMINOPHENYLARSONIC ACID p-ANILINE-ARSONIC ACID ANTOXYLIC ACID p-ARSANIL-IC ACID 4-ARSANILIC ACID ATOXYLIC ACID... 

Fig. 12.1. Some active molecules used for the haptenation of antibodies. In (a) /i-aminobenzenearsonic acid or A -(4-aminobenzoyl)-L-glutamic acid are diazotized (according to Table 12.4) and reacted separately with 4-hydroxyphenylisothiocyanate to yield ars-azo-hydroxyphenylisothiocyanate (RAPITC) and glut-azo-hydroxyphenyl-isothiocyanate (GAPITC), respectively, which differ in R. 2,4-Dinitro-l-fluorobenzene and 2,4-dinitrobenzene sulfonate are presented in (b).

It is important to note that many non-sulfonamides are known that can compete with j AB (/ -aminobenzoic acid). The most used of these is dapsone 9.17), 4,4 -di(aminophenyl)sulfone, the sheet anchor of all leprosy therapy. Others contain no sulfur atom, but have the requisite steric and electronic resemblance to pAR. For example, the insertion of a chlorine atom into either the 2- or the 3-position of pAR makes an active anti-pAB substance (Wyss, Rubin and Strandskov, 1943). Diaminobenzil 2.15) is several times more active against bacteria than sulfanilamide, and is reversed by / AB (Kuhn, Weygand and Moller, 1943). Again,/ -aminobenzenearsonic acid, atoxyl 6.2) has a typical sulfanilamide-like action (Albert, Falk and Rubbo, 1944). Although, in general, arsonic acids are not antibacterial, atoxyl forms an exception because it resembles pAR sufficiently, sterically and electronically, to compete with it. 

Aminobenzenearsonic acid, 9CI. p-Aminophenylarsonic acid. p-Aminophenylarsinic acid. Arsanilic acid, BAN, INN. 

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