Dabigatran

Characteristics Recombinant hirudins Bivalirudin Argatroban Ximelagatran and melagatran Dabigatran... [Pg.87]

Chemical structures of the thrombin inhibitors, melagatran and dabigatran, and their orally effective prodrugs, ximelagatran and dabigatran etexilate. Source From Refs, 4, 26, 33, 68,... [Pg.111]

Dabigatran etexilate is another promising oral Tl which is being evaluated in experimental and clinical studies, although the presently available data are still limited and not as comprehensive as for ximelagatran and its active form melagatran. [Pg.114]

StangierJ, Eriksson Bl, Dahl OE, etal. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement. J Clin Pharmacol 2005 45 555-563. [Pg.117]

Eriksson Bl, Dahl OE, Ahnfelt L, et al. Dose escalating safety study of a new oral direct thrombin inhibitor, dabigatran etexilate, in patients undergoing total hip replacement BISTRO I. J Thromb Haemost 2004 2 1573-1580. [Pg.117]

Efaproxiral, 45 Sleep Aid Gaboxadol, 190 Indiplon, 192 Ramelteon, 72 Superoxide Inhibitor Tetomilast, 101 Thrombin Inhibitor Dabigatran, 156 Tyrosenemia Treatment Nitisinone, 47 Uricosoric Febuxostat, 100... [Pg.244]

Clinically important, potentially hazardous interactions with abarelix, acenocoumarol, amisulpride, amprenavir, anisindione, anticoagulants, arsenic, astemizole, carbimazole, celiprolol, ciprofloxacin, dabigatran, degarelix, dicumarol, digoxin, diltiazem, enoxacin, fentanyl, fosamprenavir, gatifloxacin, grapefruit juice, lomefloxacin, methotrexate, moxifloxacin, nilotinib, norfloxacin, ofloxacin, oxprenolol, quinidine, quinolones, rifabutin, rifampin, rifapentine, ritonavir, simvastatin, sparfloxacin, sulpiride, tacrolimus, tipranavir, verapamil, warfarin, zuclopenthixol... [Pg.28]

Clinically important, potentially hazardous interactions with alprazolam, aprepitant, astemizole, atorvastatin, benzodiazepines, carbamazepine, chlordiazepoxide, cilostazol, clonazepam, clorazepate, colchicine, conivaptan, cyclosporine, dabigatran, dasatinib, diazepam, digoxin, dihydroergotamine, disopyramide, ergot alkaloids, fesoterodine, fluoxetine, flurazepam, fluvastatin, HMG-CoA reductase inhibitors, imatinib, ixabepilone, lapatinib, lopinavir, lorazepam, lovastatin, methylprednisolone, methysergide, midazolam, nilotinib, oxazepam, paroxetine, pimozide, pravastatin, prednisone, quazepam, repaglinide, rimonabant, rivaroxaban, sertraline, silodosin, simvastatin, solifenacin, temazepam, temsirolimus, tolvaptan, trabectedin, triazolam, warfarin, zidovudine... [Pg.132]

Clinically important, potentially hazardous interactions with anisindione, anticoagulants, atorvastatin, dabigatran, dicumarol, fondaparinux, simvastatin, warfarin... [Pg.139]

Clinically important, potentially hazardous interactions with abciximab, anagrelide, anticoagulants, cilostazol, clopidogrel, dabigatran, dipyridamole, eptifibatide, salicylates, ticlopidine, tirofiban. Many herbals that possess anticoagulant or antiplatelet activity... [Pg.248]

Clinically important, potentially hazardous interactions with acenocoumarol, aspirin, bivalirudin, butabarbital, capsicum, ceftobiprole, dabigatran, danaparoid, desvenlafaxine, dong quai, ginger, horse chestnut (bark, flower, leaf, seed), palifermin, red clover, salicylates, tazobactum, tirofiban... [Pg.276]

Clinically important, potentially hazardous interactions with amiodarone, amprenavir, anisindione, antacids, anticoagulants, aprepitant, atazanavir, atovaquone, beclomethasone, buprenorphine, corticosteroids, cortisone, cyclosporine, cyproterone, dabigatran, dapsone, darunavir, delavirdine, dexamethasone, dicumarol, digoxin, eszopiclone, flunisolide, fosamprenavir, gadoxetate, gestrinone, halothane, imatinib, isoniazid, itraconazole, ketoconazole, lapatinib, lorcainide, methylprednisolone, midazolam, nelfinavir, nifedipine, oral contraceptives, phenylbutazone, prednisone, protease inhibitors, pyrazinamide, ramelteon, ritonavir, saquinavir, solifenacin, sunitinib, tacrolimus, telithromycin, temsirolimus, tipranavir, tolvaptan, trabectedin, triamcinolone, triazolam, voriconazole, warfarin, zaleplon... [Pg.504]

Clinically important, potentially hazardous interactions with acebutolol, amiodarone, aspirin, atenolol, atorvastatin, betaxolol, carbamazepine, carteolol, celiprolol, donidine, dabigatran, dantrolene, digoxin, dofetilide, epirubicin, eplerenone, erythromycin, esmolol, eucalyptus, everolimus, lovastatin, metoprolol, mistletoe, nadolol, oxprenolol, penbutolol, pindolol, propranolol, quinidine, ranolazine, sibutramine, simvastatin, timolol, trabectedin... [Pg.611]

Platelet aggregation inhibitors Dabigatran etexilate [138, 139] Ticagrelor [139]... [Pg.94]

Dabigatran Pradaxa Boehringer Ingelheim 2008 Thrombin Venous thrombolic events 137... [Pg.118]

Thrombin Inhibitors Melagatran/Ximelagatran and Dabigatran as Drugs for the Treatment of Thromboembolytic Disease... [Pg.127]

In 2008, dabigatran (BIBR-953) had also been approved by the FDA for use as an anticoagulant for the treatment of thromboembolytic diseases.It is marketed as a double prodrug, dabigatran etexilate. [Pg.127]

Figure 5.9 Structures of ximelagatran (top, prodrug of melagatran), melagatran (middle) and dabigatran (bottom).

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