D-Glucose-1 -phosphate

Biologically formed D-glucosone phosphate has been separated from d-glucosone by paper chromatography, using ethyl acetate-amyl alcohol-formamide (1 2 3) as developer. This solvent mixture does not completely separate D-glucosone phosphate from D-glucose 6-phosphate and D-fructose 1-phosphate.16... 

Lohmann118 detected an enzyme in muscle extracts, found later in plants and yeasts,104Co) 117,118 termed phosphoglucoisomerase, (optimum pH 9), which catalyzes the interconversion of D-glucose 6-phosphate (XVI) and D-fructose 6-phosphate (XVII). At equilibrium, which is attained rapidly, there is about 70 % of the former and 30 % of the latter. In a similar conver-... 

The oxidative pathway for the metabolism of D-glucose 6-phosphate (XLV), distinctive from the glycolytic, Embden-Meyerhof route (see p. 200) and known as the hexose monophosphate shunt, was suggested by certain experiments of Warburg,200 Gerischer,207 Lipmann,208 and Dickens209... 

Heyns and Meinecke266 found that D-glucosamine results from the action of ammonia on D-fructose this observation raises the possibility that D-glucosamine arises from D-glucose 6-phosphate via D-fructose 6-phosphate. 

A novel synthesis of D-glucose 6-phosphate (in 55% yield) has been reported it involves alcoholysis of the cyclic phosphate of catechol with 1,2-O-isopropylidene-a-D-glucofuranose, followed by acid hydrolysis of the so-formed phosphoric diester.192 The reagent... 

Synthesis of sucrose 6 -phosphate by an enzymic method using uridine 5 -(a-D-glucopyranosyl diphosphate) plus D-glucose 6-phosphate has been reported.126-131 The first, unambiguous, chemical synthesis of sucrose 6 -phosphate was achieved by Buchanan and coworkers.18 The reaction of 2,3,4,6,l, 3, 4 -hepta-0-acetylsucrose, prepared by five steps of synthesis, with cyanoethyl phosphate in pyridine gave a crude product from which sucrose 6 -phosphate was isolated as the barium salt. 

G9. Glaser, L., and Brown, D. H., Purification and properties of D-glucose-6-phosphate dehydrogenase. ]. Biol. Chem. 216, 67-79 (1955). 

D-Glucose 6-phosphate is converted enzymically into L-wyo-inositol 1-phosphate (20) in a process which requires NAD+. The base-catalysed cyclization of d-xylo-hexos-5-ulose 6-phosphate (21), followed by reduction with borohydride, leads to (20) and epi-inositol 3-phosphate (22) (Scheme 3).59 This has been put forward as a chemical model for the enzymic synthesis. The phosphorylation of inositols with polyphosphoric acid has been described80 and the p-KVs of inositol hexaphosphate have been determined by 31P n.m.r.61... 

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