D2 receptor antagonist

Prolactin is peptide hormone secreted by the pituitary gland. It acts on prolactin receptors in breast tissue where it stimulates production of casein and lactalbu-min. It also acts on the testes and ovaries to inhibit the effects of gonadotrophins. Since the secretion of prolactin is under tonic dopaminergic inhibition by the hypothalamus, dopamine D2-receptor antagonists... 

Derivatives of (S) N-[(l-ethyl-2-pyrrohdinyl)methyl]-6-methoxy benzamide 3 are dopamine D2 receptor antagonists. Samanta et al. obtained the following MLR QSAR for 49 derivatives with the general structure 3 [30] ... 

Typical and atypical antipsychotic medications (D2-receptor antagonists)... 

M., Humphrey, G.R. et al. on the long term factory process for the production of a prostaglandin D2 receptor antagonist - unprecedented asymmetric hydrogenation of an indole Fxo-Cyclic Trisubstituted a,(i-Unsaturated Acid. 

Ongini E., Bonizzoni E., Ferri N., Milani S., Trampus M. (1993). Differential effects of dopamine D1 and D2 receptor antagonist antipsychotics on sleepwake patterns in the rat. J. Pharmacol. Exp. Then... 

Broening, H.W., Morford, L.L., Vorhees, C.V. Interactions of dopamine D, and D2 receptor antagonists with D-methamphetamine-induced hyperthermia and striatal dopamine and serotonin reductions. Synapse. 56 84, 2005. 

Other local anaesthetics such as procaine (4) and procainamide (5) were also shown to be antagonists of the sympathetic neuronal 5-HT3 receptor at concentrations well below those causing anaesthesia and led to the testing of metoclopramide (6), a D2 receptor antagonist and stimulant of gastrointestinal motility. This compound too was found to be a potent antagonist (pA2 7.2) at 5-HT3 receptors [52]. 

Rodent models thus provide opportunities to explore the relationship between dopaminergic function, attention and consciousness. Based upon the well designed study of Granon et al. (2000) showing a clear improvement of attentional performance after the infusion of a D1 agonist into the prefrontal cortex, further study of cortical arousal and variability of reaction times in these models may provide important information. The preliminary data indicating that D2 receptor antagonists may increase cortical arousal (Sebban et al., 1999) is contrary to expectation and requires confirmation... 

---