Cytostatic action

It is noteworthy that except for the Rieske center in Complex III, Complexes I and 11 are home to all the iron-sulfur clusters in the mitochondrial electron transfer chain and consequently most of the iron-containing carriers in the entire sequence. Hibbs subsequently showed that CAM-injured cells lose a substantial portion of their total intracellular iron (Hibbs et al., 1984) [later studies specifically identified loss of mitochondrial iron (Wharton et al., 1988)] and Drapier and Hibbs (1986) showed that the activity of another iron-sulfur-containing enzyme, aconitase, is also lost. In early 1987 Hibbs reported that the cytostatic actions of CAMs requires the presence of only one component in culture medium, L-arginine (Hibbs et al., 1987b). Thus, the stage was set for the discovery of a unique reactive species that targets intracellular iron, produced by CAMs. 

Study of the V-typc sample (Table 2) has shown that D, D2, and D3 doses inhibit cell growth by 9.7, 18.6, and 24.2%, respectively. This is close to the effect of Platidiam Ptd-L solution from which the drug adsorption was carried out. Results obtained show that almost all Platidiam is released from the magnetically sensitive carrier into the cultivated medium. Increased cytostatic action of magnetically sensitive nanocomposites (Platidiam carriers) may be achieved by means of solvent, adsorption time, and temperature optimization. 

A. L. Petranovska, O. M. Fedorenko, P. P. Gorbik, L. P. Storozhuk, O. O. Chuiko, and V. F. Chekhun, The release dynamics of cytostatic action drug Platidiam from the surface of ferreed nanocomposite, Medical Chemistry 7(2), 75-78 (2005). 

Von Pawel J. Topotecan (Hycamtin) potent cytostatic action by selective topoisomerase I inhibition. Onkologie 1997 20 380-6. 

Acitretin is currently the only retinoid licensed in the United Kingdom for the treatment of psoriasis and is only available for treatment of patients in hospitals. It is given orally and has anti-inflammatory and cytostatic actions. This is useful in inflammatory psoriasis. The half-life of acitretin is about two days. However, there is a high risk of teratogenesis and women must use adequate contraception and stop treatment for two years before conception. 

To determine whether the cytostatic action of DETA/NO could be continued for substantially longer than 22 hr and, if so, whether toxic effects would appear, a somewhat different protocol was used. Several cultures of... 

Both in vitro and in vivo results are promising in the sense that, by applying a magnetic held to the part of the body where cytostatic action is needed, magnetic particles can be attracted and held in that position, thus increasing the drug concentration there and hindering the release of these potent compounds in other parts of the body (140,141). 

These results clearly underline that the antitumor activity of cyclopentadienyl metal complexes cannot simply be ascribed to the isolated action of free cyclopentadiene molecules released from a decomposing polymer [(C5H5)Ti0]402, as was postulated recently The hypothesis that the cyclopentadienyl ring ligands in metallocene diacido and fenicenium complexes may play an important, perhaps crucial, role for the cytostatic action of these compounds would certainly explain why structurally quite different cyclopentadienyl metal complexes like tetrahedral metallocene (Fig. 4) and linear metal-licenium (Fig. 5) complexes are equally effective and characterized by a similar spectrum of activity, especially as cyclopentadiene can be released from the complexes by hydrolytic cleavage of the cyclopentadienyl-metal bond On the other hand, the complexed metal atoms also seem to play an important role whether as a kind of carrier of one or both cyclopentadienyl rings to the site of action, or an anchor capable of... 

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