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Cytoplasmic delivery

Tamura A, Oishi M, Nagasaki Y (2009) Enhanced cytoplasmic delivery of siRNA using a stabilized polyion complex based on PEGylated nanogels with a cross-linked polyamine structure. Biomacromolecules 10 1818-1827... [Pg.21]

Itaka K, Harada A, Yamasaki Y, Nakamura K, Kawaguchi H, Kataoka K (2004) In situ single cell observation by fluorescence resonance energy transfer reveals fast intra-cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine. J Gene Med 6 76-84... [Pg.29]

L Huillier, P.J., Davis, S.R. and Bellamy, A.R. (1992) Cytoplasmic delivery of ribozymes leads to efficient reduction in alpha-lactalbumin mRNA levels in Cl 271 mouse cells. UMBO. J., 11,4411 1418. [Pg.63]

Roux E, Francis M, Winnik FM et al (2002) Polymer based pH-sensitive carriers as a means to improve the cytoplasmic delivery of drugs. Int J Pharm 242 25-36... [Pg.250]

Oishi M, Hayama T, Akiyama Y, Takae S, Harada A, Yamasaki Y, Nagatsugi F, Sasaki S, Nagasaki Y, Kataoka K (2005) Supramolecular assemblies for the cytoplasmic delivery of antisense oligodeoxynucleotide polylon complex (PIC) micelles based on polyethylene glycol)-S,S-oligodeoxynucleotide conjugate. Biomacromolecules 6 2449-2454... [Pg.162]

Leroux J-C (ed) (2004) pH-responsive carriers for enhancing the cytoplasmic delivery of macromolecular drugs. Adv Drug Deliv Rev 56(7) 925-1050... [Pg.423]

Chu C-J etal (1990) Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture. Pharm Res 7 824-834... [Pg.423]

Cationic lipids can destabilize a cellular membrane because of its intrinsic detergent property. Therefore, destabilization of endosomal and/or lysosomal membrane may be a contribution from the cationic lipids itself In the same context, it was shown that the cationic lipid/DOPE or cationic lipid/cholesterol liposome formulation exhibit surface anisotropies in terms of increased liposomal surface pH (161,162). The surface pH of the liposomal formulations exhibits at least two pH units higher than the pH of the solution at which they are made. Therefore, a liposomal solution made at physiological pH may in reality exhibit a surface pH > 9, which is detrimental for both the stability of endosome and activity of lysosomal enzymes. Endosomal disruptions were also done with fusogenic peptides, which promote pH-dependent fusion of small liposomes when associated with lipid bilayer. When these peptides were co-delivered with lipid/DNA complex, they imparted formidable endosomal disruption by changing its usual random coil conformation into amphipathic a-helix conformation at lower pH, resulting in consequent cytoplasmic delivery of DNA (163). [Pg.662]

Jensen KD, Nori A, Tijerina P, Kopeckova P, Kopecek J. Cytoplasmic delivery and nuclear targeting of synthetic macromolecules. J Cont Rel 2003 87 89-105. [Pg.84]

Kono K, Igawa T, Takagishi T. Cytoplasmic delivery of cal-cein mediated by liposomes modified with a pH-sensitive poly(ethylene glycol) derivative. Biochim Biophys Acta 1997 1325 143-154. [Pg.191]

M. Oishi, J. Nakagomi, T. Ishii and Y. Nagasaki, Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing. Chem. Lett., 35,1046-1047 (2006). [Pg.813]

Straubinger, R. M., N. Duzgunes and D. Papahadjopoulos, 1985, pH-sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules. FEES Lett 179 148-154. [Pg.23]

Anionic polyelectrolytes have been used in the development of new intracellular delivery systems by membrane destabilizing mechanisms (Wasungu and Hoekstra, 2006).These polymers can be tailored to interact actively with phospholipid membranes upon external stimulation, such as acidification of the surrounding medium. This strategy has been exploited to improve the cytoplasmic delivery of biomolecules (DNA, proteins) that enter cells by endocytosis and end up in acidic organelles (Gupta et al, 2005). [Pg.75]

Mady, M. M., Ghannam, M. M., Khahl, W. A., MiiUer, R., and Fahr, A. 2009. Efficiency of cytoplasmic delivery by non-cationic liposomes to cells in vitro A confocal laser scanning microscopy study. Phys Med 25 88-93. [Pg.387]

Boomer JA, Qualls MM, Inerowicz HD, Haynes RH, Patri VS, Kim J-M, Thompson DH (2009) Cytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugate. Bioconjugate Chem 20 47-59... [Pg.185]

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See also in sourсe #XX -- [ Pg.359 , Pg.363 , Pg.364 ]



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Cytoplasm

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