Cytomegalo virus infections

Bettinger, D., Mougin, C, and Lab, M (1994) Rapid detection of cytomegalo-virus-infection by in situ polymerase chain reaction on MRC5 cells inoculated with blood specimens J Virol Methods 49, 59-66... 

Nucleosides - Laboratory data on 9-p-D-arabinofuranosyladenine (Ara-A) was extensively discussed in a series of reports30,31,32,33,34,35. Ara-A was effective against herpes simplex infections of mice by IP, SC, oral and topical treatment started either prior to or after infection. Topical treatment with Ara-A of scarified hamsters eyes infected with herpes simplex prevented death and healed the eyes. Although high doses of compound were necessary, the material had a low order of animal toxicity with no mortality in mice at 7,950 mg/kg orally and an IP LD q of 4,677 mg/kg. In tissue culture antiviral activity was reported against strains of adeno, cytomegalo, vaccinia, varicella and human and simian strains of herpes viruses. The topical activity and low toxicity of Ara-A Indicate it is a promising candidate for treatment of herpes infections. 

---