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Cytochromes P450 regulation

Primary human hepatocytes in particular have not yet proven to be compatible with cryopreservation (Utesch et al., 1992), therefore studies must be performed when the tissue becomes available. Characterization of the enzyme composition of the tissue derived from an individual must be conducted in parallel with characterization of the unknown xenobiotic. This can lead to the devotion of considerable experimental effort to studies which, in the end, do not meet quality control criteria. Despite these limitations, human hepatocytes are uniquely suited for studies of cytochrome P450 regulation and also provide the only current system which maintains a balanced and physiological ratio of cofactors and individual Phase I and Phase II enzymes. [Pg.185]

Morgan ET, Li-Masters T, Cheng PY. Mechanisms of cytochrome P450 regulation by inflammatory mediators. Toxicology 2002 181-182 207-210. [Pg.194]

Cytochrome P450 regulation by chemicals and clinical consequences... [Pg.1930]

Jover, R., Bort, R., Gomez-Lechon, M. J., and Castell, J. V. (2001) Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes a study using adenovirus-mediated antisense targeting. Hepatology 33, 668-675. [Pg.295]

Correia MA, Sinclair PR, De Matteis F (2010) Cytochrome P450 regulation the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal. Drug Metab Rev 43 1-26... [Pg.239]

Recchi C, Sclav B, Rauzier J, Gicquel B, Reyrat JM (2003) Mycobacterium tuberculosis Rvl395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation. J Biol Chem 278 33763-33773... [Pg.407]

Nuclear Receptor Regulation of Hepatic Cytochrome P450 Enzymes... [Pg.427]

Nuclear Receptor Regulation of Hepatic Cytochrome P450 Enzymes. Figure 1 General mechanism for transcriptional activation of CYP genes by xenochemicals that activate their cognate xeno-receptor proteins. In the case of Ah receptor, the receptor s heterodimerization partner is Arnt, whereas in the case of the nuclear receptors CAR, PXR, and PPARa, the heterodimerization partner is RXR. The coactivator and basal transcription factor complexes shown are each comprised of a large number of protein components. [Pg.890]

Honkakakoski P, Negishi M Regulation of cytochrome P450 (GYP) genes by nuclear receptors. BiochemJ 2000 347 321. [Pg.632]

Andersson T, L Fortin (1992) Regulation of the cytochrome P450 enzyme system in fish. Aquat Toxicol 24 1-20. [Pg.100]

Anderson, K. E. Kappas A. (1991). Dietary regulation of cytochrome P450. Annu. Rev. Nutr., 11, 141-67. [Pg.34]

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