Target antigen cytochrome

Proteins such as cytochrome c are not good target antigens for the determination of species of origin because the structures of these proteins in evolutionarily distant species are very similar. Serum albumin, on the other hand, is a rapidly changing protein (Table I) that is amenable to complete immunochemical analysis with both polyclonal and monoclonal antibodies (14-16). Albumins from thousands of pairs of vertebrate species have been compared immunochemically, and the results have been used to measure evolutionary distances (22). 

With a genetic or disease-related predisposition, the intake of medicaments and their subsequent catabolism in the biotransformatory system sometimes lead to the formation of reactive metabolites, (s. p. 55) (s. fig. 3.11) These can bind to components of the cytochrome system. After cytolysis, they may become the target antigens of antibodies, (s. p. 544) (s. fig. 29.1) This has been ascertained, for example, for carbamazepine (LMK 3),... 

Robin MA, Maratrat M, Le Roy M, et al. Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2Cll-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. J Clin Invest 1996 98 1471-1480. 

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