Monooxygenases cytochrome P-450-dependent

Miranda, C.L., M.C. Henderson, J.L. Wang, H.S. Nakaue, and D.R. Buhler. 1987. Effects of polychlorinated biphenyls on porphyrin synthesis and cytochrome P-450-dependent monooxygenases in small intestine and liver of Japanese quail. Jour. Toxicol. Environ. Health 20 27-35. 

Schwen, R.J. and G.J. Mannering. 1982a. Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake. II. Monooxygenase activities. Comp. Biochem. Physiol. 71B 437-443. 

Fig. 10.4 Reaction catalyzed by the cytochrome P-450-dependent monooxygenase (5)-7V-methylcoclaurine 3 -hydroxylase (CYP80B1) along the (

PAULI, H.H., KUTCHAN, T.M., Molecular cloning and functional heterologous expression of two alleles encoding (5)-Y-methylcoclaurine 3 -hydroxylase (CYP80B1), a new methyl jasmonate-inducible cytochrome P-450-dependent monooxygenase of benzylisoquinoline alkaloid biosynthesis, Plant J., 1998,13, 793-801. 

Robacker KM, Kulkarni AP, Hodgson E. 1981. Pesticide induced changes in the mouse hepatic microsomal cytochrome P-450-dependant monooxygenase system and other enzymes. J Environ Sci Health (Part B Pestic Food Contam Agric Wastes) 16(5) 529-546. 

Yarbrough JD, Grimley JM, Alley EG. 1986a. Induction of the hepatic cytochrome P-450 dependent monooxygenase system by cis- and trans-5,10-dihydrogen mirex. Toxicol Lett 32 65-71. 

Dahl, A.R. Hadley, W.M. (1983) Formaldehyde prodnction promoted by rat nasal cytochrome P-450-dependent monooxygenases with nasal decongestants, essences, solvents, air pollutants, nicotine, and cocaine as substrates. Toxicol, appl. Pharmacol, 67, 200-205 Dayal, R., Gescher, A., Harpur, E.S., Pratt, I. Chipman, J.K. (1989) Comparison of the hepa-toxicity in mice and the mutagenicity of three nitroalkanes. Fundam. appl Toxicol, 13, 341-348... 

The ability of PBBs to induce hepatic Phase I xenobiotic metabolizing enzymes (cytochrome P-450-dependent monooxygenases) is well documented (Dannan et al. 1978b, 1982a, 1982b, 1983 Ecobichon et al. 1979 Moore et al. 1978, 1979 Parkinson et al. 1983 Robertson et al. 1982 Schramm et al. 1985). PBB mixtures were classified as "mixed-type" inducers of hepatic microsomal monooxygenases and... 

Meyer, K., Cusumano, J. C., Sommerville, C., and Chappie, C. C. S., 1996, Ferulate-5-hydroxylase from Arabidopsis thaliana defines a new family of cytochrome P-450 dependent monooxygenases, Proc. Natl. Acad. Sci. USA 93 6869-6874. 

Dahl, A.R. 1986. Possible consequences of cytochrome P-450 dependent monooxygenases in nasal tissues, in Toxicology of the nasal passages, ed.G.S. Barrow, 263. Washington D.C. Hemisphere. 

Cytochrome P-450-dependent monooxygenases are widely distributed in living organisms (e.g., mammals, insects, fish, yeasts, plants). In humans, they exist in several organs and tissues with a maximum level in the liver. These monooxygenases are multienzymatic systems that are able to transfer electrons from NADPH or NADH to their terminal component, cytochrome P-450, which contains the site of activation of dioxygen and substrates. They catalyze the insertion of only one oxygen atom of 02 into the substrate (Eq. 7). 

The biochemical mechanism of carbon tetrachloride toxicity has been investigated in detail. The cytochrome P-450-dependent monooxygenase system acts on CC14 in the liver to produce the C13C free radical ... 

MADYASTHA, K.M., RIDGWAY, J.E., DWYER, J.G., COSCIA, C.J., Subcellular localization of a cytochrome P-450-dependent monooxygenase in vesicles of the higher plant Catharanthus roseus. J. Cell Biol., 1977,72,303-313. 

Cytochrome P-450-dependent monooxygenases Lipoxygenases (non-heme Fe-dependent) L M M... 

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