Cytochrome P450-mediated metabolism

Korzekwa K, Ewing TJ, Kocher JP, Carlson TJ. Models for cytochrome P450-mediated metabolism. In Borchardt RT, Kerns EH, Lipinski CA, Thakker DR,... 

Chauret, N., Gauthier, A. and Nicoll-Griffth, D.A. (1998) Effect of common solvents on in vitro cytochrome P450 mediated metabolic activities in human liver microsomes. Drug Metabolism and Disposition The Biological Fate of Chemicals, 26, 1-4. 

CKD may alter nonrenal clearance of drugs as the result of changes in cytochrome P450-mediated metabolism in the hver and other organs. The clinical reductions in nonrenal clearance in CKD are generally proportional to the reductions in glomerular filtration rate (Table 77-1). 

Korzekwa KR, Jones JP. Predicting the cytochrome P450 mediated metabolism of xenobiotics. 

Ansede, J. H. Thakker, D. R. High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism. / Pharm Sci 2004, 93, 239-255. 

Waller, C. L., Evans, M. V., and McKinney, J. D. (1996) Modeling the cytochrome P450-mediated metabolism of chlorinated volatile organic compounds. Drug Metab. Dispos. 24, 203-210. 

Isoniazid inhibits cytochrome P450 enzyme function and thus can interact with drugs that are subject to cytochrome P450 mediated metabolism like warfarin and the antiepileptic agents phenytoin and car-bamazepine. 

Breinholt, V.M., Offord, E.A., Brouwer, C., Nielsen, S.E., Brosen, K., and Eriedberg, T., In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem. Toxicol, 40, 609, 2002. 

Vang, O., Wallin, H., Doehmer, J. Autrup, H. (1993) Cytochrome P450-mediated metabolism of tumour promoters modifies the inhibition of intercellular cormnunication a modified assay for tumour promotion. Carcinogenesis, 14, 2365-2371 Verschueren, K. (1996) Handbook of Environmental Data on Organic Chemicals, 3rd Ed., New York, Van Nostrand Reinhold, pp. 866-873 Vitali, M., Leoni, V, Chiavarini, S. Cremisini, C. (1993) Determination of 2-ethyl-l-hexanol as contaminant in drinking water. J. Assoc, off anal. Chem. int., 76, 1133-1137... 

Table 3 Inhibition of Human Cytochrome P450-Mediated Metabolism by Aliquots of Aqueous Extracts of SJW Tablets (% Inhibition SD 5mg/mL Stock Solutions Except Where Noted n = 3-6)...

Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003 10(4) 334—342. 

Isosteric substitution of the C-2 hydrogen atom of valproic acid (12) with a fluorine atom affords 2-fluorovalproic acid (22), which causes significantly less hepatoxicity than valproic acid, although a reduction in anticonvulsant properties is also observed [59, 60]. The hepatoxicity of 12 involves hepatic cytochrome P450-mediated metabolism to its 4-ene metabolite (14), which undergoes further metabolism, specifically mitchondrial (3-oxidation, to provide ( )-2-propyl-2,4-pentadienoic add (23), a reactive electrophilic metabolite [59, 60]. 

Vang, 0., Wallin. H.. Doelnner, J. Autrup, H. (1993) Cytochrome P450-mediated metabolism... 

Gan LS, Moseley MA, Khosla B, et al. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug Metab Dispos 1996 24(3) 344-349. 

Frye RF, Zgheib NK, Matzke GR, et al. (2006) Liver disease selectively modulates cytochrome P450-mediated metabolism. Clin Fharmacol Ther 80 235-245. 

Yasumori, T. Nagata, K. Yang, S. K. Chen, L.-S. Murayama, N. Yamazoe, Y Kato, R. Cytochrome P450 mediated metabolism of diazepam in human and rat involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner, Pharmacogenetics 199i, 3,291-301. 

In hepatic microsomes, omeprazole inhibited cytochrome P450-mediated metabolic reactions in vitro. This effect was comparable to the inhibition caused by cimetidine with respect to the extent of the inhibitory effect and the effective concentrations [110]. Under well-defined clinical conditions, an... 

Kerbusch T, Jansen RL, Mathot RA, Huitema AD, Jansen M, van Rijswijk RE, Beijnen JH. Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin. Clin Pharmacol Ther 2001 70(2) 132-41. 

Korzekwa, K.R. and Jones, J.P. (1993) Predicting the cytochrome P450 mediated metabolism of xenobiotics. Pharmacogenetics, 3 (1), 1-18. 

Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes. Drug Metab. Dispos. 26, 1—4. 

A sampling of commonly used drugs with cytochrome P450-mediated metabolism inhibited by ketoconazole or other azoles includes chlordiazepoxide, cisapride, cyclosporine, didanosine, fluoxetine, loratadine, lovastatin, methadone, nifedipine, phenytoin, quinidine. theophylline, verapamil, warfarin, and zolpidem. 

Alterbcrry, T, Burnett, W.. and Chambers, 1. (1997). Age-related differences in parathion and chlorpyrifos toxicity in male rats Target and nontarget esterase sensitivity and cytochrome P450-mediated metabolism, toidcol Appi Pharmacol. 147, 411-418. 

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