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Cytidine 5’-diphosphate CDP

The sugar nucleotides (an uninformative name that has been used for glycosyl nucleotides, or more strictly, glycosyl esters of nucleoside di- or mono-phosphates) were discussed in this Series12 in 1973. Since then, accumulation of new data about these derivatives has continued, and now, about 35 representatives of this class are known to participate in the biosynthesis of polysaccharide chains of bacterial polymers (for a survey, see Ref. 13). These include glycosyl esters of uridine 5 -diphosphate (UDP), thymidine 5 -diphosphate (dTDP), guanosine 5 -diphosphate (GDP), cytidine 5 -diphosphate (CDP), cytidine 5 -monophosphate (CMP), and adenosine 5 -diphosphate (ADP). [Pg.280]

FIGURE 9.8 CTP synthase. CTP synthase catalyzes the transfer of an amino group to UTP, gCTierating CTP. Glutamine serves as the donor of the amino nitrogen. Folate is not involved in the synthesis of CTP. Cytidine 5 -diphosphate (CDP) is distinguished in that it is used in lipid metabolism, where it takes the forms of CDP-choline, CDP-ethanolamine, and CDP-diacylglycerol. [Pg.502]

Figure 12 Evidence for an enhanced stability of the Cd as well as the Ca ", Mg, and Co " 1 1 complexes (eq. 2) of ADP ( ), IDP ((g)), and GDP " (O), based on the relationship between log M(R-DP) P H(R-DP) simple M(R-DP) complexes (O), where R-DP = phenyl diphosphate (PhDP ), methyl diphosphate (MeDP ), uridine 5 -diphosphate (UDP ), cytidine 5 -diphosphate (CDP ), thymidine [= l-(2-deoxy-P-D-ribofuranosyl)thymine] 5 -diphosphate (dTDP ), and z-butyl diphosphate (BuDP ) (from left to right). The least-squares lines (eq. 15) are drawn through the indicated six data sets taken from ref. [115]. The points due to the M /NDP systems are based on the values listed in Table 10. The vertical broken lines emphasize the stability differences from the reference lines they equal log m/ndp as defined in analogy to equation (14) (see also Table 10, column 4). All the plotted equilibrium constants refer to aqueous solutions at 25°C and / = 0.1 M (NaNOg). Figure 12 Evidence for an enhanced stability of the Cd as well as the Ca ", Mg, and Co " 1 1 complexes (eq. 2) of ADP ( ), IDP ((g)), and GDP " (O), based on the relationship between log M(R-DP) P H(R-DP) simple M(R-DP) complexes (O), where R-DP = phenyl diphosphate (PhDP ), methyl diphosphate (MeDP ), uridine 5 -diphosphate (UDP ), cytidine 5 -diphosphate (CDP ), thymidine [= l-(2-deoxy-P-D-ribofuranosyl)thymine] 5 -diphosphate (dTDP ), and z-butyl diphosphate (BuDP ) (from left to right). The least-squares lines (eq. 15) are drawn through the indicated six data sets taken from ref. [115]. The points due to the M /NDP systems are based on the values listed in Table 10. The vertical broken lines emphasize the stability differences from the reference lines they equal log m/ndp as defined in analogy to equation (14) (see also Table 10, column 4). All the plotted equilibrium constants refer to aqueous solutions at 25°C and / = 0.1 M (NaNOg).
Inhibition of Cytidine-5 -diphosphate-D-Glucose 4,6-Dehydratase (CDP D-Glucose 4,6-Dehydratase)... [Pg.266]

CDK2, cell division kinase 2 cDNA, complementary DNA CDP, cytidine 5 -diphosphate CDPK, Ca2+-dependent protein kinase, calmodulin domain protein kinase CFTR, cystic fibrosis transmembrane conductance regulator cGMP, 3, 5 -c.yclic guanosine monophosphate cGMP PDE, cyclic GMP phosphodiesterase... [Pg.840]

Scheme L Synthesis of a2,64inked sialyl-N-acetyllactosamine using a one-pot multi-enzyme system with in situ regeneration of CMP-Neu5Ac. Abbreviations for enzymes CSS, CMP-sialic acid synthetase NMK, nucleoside monophosphate kinase PK, pyruvate kinase PPase, pyrophosphatase. Abbreviations for compounds PEP, phosphoenolpyruvate ADP, adenosine 5 -diphosphate ATP, adenosine 5 -triphosphate CMP, cytidine 5-monophosphate CDP, cytidine 5 -diphosphate CTP, cytidine 5-triphosphate LacNAc, N-acetyllactosamine NeuSAc, N-acetylneuraminic acid PPi, inorganic pyrophosphate. Scheme L Synthesis of a2,64inked sialyl-N-acetyllactosamine using a one-pot multi-enzyme system with in situ regeneration of CMP-Neu5Ac. Abbreviations for enzymes CSS, CMP-sialic acid synthetase NMK, nucleoside monophosphate kinase PK, pyruvate kinase PPase, pyrophosphatase. Abbreviations for compounds PEP, phosphoenolpyruvate ADP, adenosine 5 -diphosphate ATP, adenosine 5 -triphosphate CMP, cytidine 5-monophosphate CDP, cytidine 5 -diphosphate CTP, cytidine 5-triphosphate LacNAc, N-acetyllactosamine NeuSAc, N-acetylneuraminic acid PPi, inorganic pyrophosphate.
Chloroform solutions of dioleoylphosphatidylcholine (DOPC), dioleoyl-phosphatidylethanolamine (DOPE), dioleoylphosphatidylserine (DOPS), dioleoylphosphatidic acid (DOPA), and phosphatidylinositol (PI) from soybean are purchased from Avanti Polar Lipids (Alabaster, AL). Phosphatidylinositol 4-phosphate (PI4P), phosphatidylinositol 4,5-biphosphate (PIP2), and cytidine 5 -diphosphate-diacylglycerol (CDP-DAG) are obtained from Sigma (St. Louis, MO). Cholesterol is purchased from Nacalai... [Pg.84]

Figure 10 Chemical structures of adenosine 5 -monophosphate (n = 1 AMP ), adenosine 5 -diphosphate (n = 2 ADP "), and adenosine 5 -triphosphate (n = 3 ATP ) as well as of cytidine 5 -monophosphate (n = 1 CMP, cytidine 5 -diphosphate (n = 2 CDP ), and cytidine 5 -triphosphate (n = 3 CTP ) in their dominating anti conformation [11-14,50]. Note, the triphosphate chain in nucleoside 5 -triphosphates (NTP ) is labeled a, P, and y, where y refers to the terminal phosphate group (see also Figure 9) for nucleoside 5 -diphosphates (NDP ) the situation is analogous with a and P (see Figure 9). The adenine and cytosine residues in the nucleotide structures shown above may be replaced by one of the other nucleobase residues shown in Figiue 1 if this substitution is done in the way the bases are depicted within the plane (Figure 1), then the anti conformation will also result for the corresponding nucleoside 5 -phosphates. The abbreviations AMP, ADP , ATP , IMP, etc. in this text always represent the 5 -derivatives 2 - and 3 -derivatives are defined by 2 AMP, 3 AMP, etc. in a few instances where uncertainties might otherwise occur, the abbreviations 5 AMP , 5 ADP , etc. are also used. Figure 10 Chemical structures of adenosine 5 -monophosphate (n = 1 AMP ), adenosine 5 -diphosphate (n = 2 ADP "), and adenosine 5 -triphosphate (n = 3 ATP ) as well as of cytidine 5 -monophosphate (n = 1 CMP, cytidine 5 -diphosphate (n = 2 CDP ), and cytidine 5 -triphosphate (n = 3 CTP ) in their dominating anti conformation [11-14,50]. Note, the triphosphate chain in nucleoside 5 -triphosphates (NTP ) is labeled a, P, and y, where y refers to the terminal phosphate group (see also Figure 9) for nucleoside 5 -diphosphates (NDP ) the situation is analogous with a and P (see Figure 9). The adenine and cytosine residues in the nucleotide structures shown above may be replaced by one of the other nucleobase residues shown in Figiue 1 if this substitution is done in the way the bases are depicted within the plane (Figure 1), then the anti conformation will also result for the corresponding nucleoside 5 -phosphates. The abbreviations AMP, ADP , ATP , IMP, etc. in this text always represent the 5 -derivatives 2 - and 3 -derivatives are defined by 2 AMP, 3 AMP, etc. in a few instances where uncertainties might otherwise occur, the abbreviations 5 AMP , 5 ADP , etc. are also used.
Cytidine phosphates cytidine S -monophosphate (CMP, cytidylic acid, M, 323.2), cytidine 5 -diphos-phate (CDP, M, 403.19) and cytidine 5 -triphosphate (CTP, M, 483.16). For structure, see e. g. Pyrimidine biosynthesis. CTP is a precursor of RNA synthesis, while deoxy-CTP is a precursor of DNA synthesis. CDP may be regarded as the coenzyme of phospholipid biosynthesis (see Membrane lipids) (activated choline is CDP-choline). Glycerol and the sugar alcohol, ribitol, are also activated by bonding to CDP (see Nucleoside diphosphate sugars). Reduction of ribose... [Pg.150]

Cytidine 5 -(trihydrogen diphosphate) hydroxide mono[2-(trimethylammo-nio) ethyl] ester. Choline hydroxide 5 -ester with cytidine 5 -(trihydrogen pyrophosphate) inner salt. CDP-Choline. Cytidine diphosphocholine. CiticoUne, INN, JAN. Cereb. Citidoline. Colite. Cyscholin. Nicholin [987-78-0]... [Pg.272]

Cytidine 5 -(trihydrogen diphosphate) mono(2,3-dihydroxypropyl) ester(S), 9CI. CDP-glycerol [6665-99-2]... [Pg.272]

Figure 21-3 Major pathways of synthesis of fatty acids and glycerolipids in the green plant Arabidopsis. The major site of fatty acid synthesis is chloroplasts. Most is exported to the cytosol as oleic acid (18 1). After conversion to its coenzyme A derivative it is converted to phosphatidic acid (PA), diacylglycerol (DAG), and the phospholipids phosphatidylcholine (PC), phosphatidylinositol (PI), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE). Desaturation also occurs, and some linoleic and linolenic acids are returned to the chloroplasts. See text also. From Sommerville and Browse.106 See also Figs. 21-4 and 21-5. Other abbreviations monogalactosyldiacylglycerol (MGD), digalactosyldiacylglycerol (DGD), sulfolipid (SL), glycerol 3-phosphate (G3P), lysophosphatidic acid (LPA), acyl carrier protein (ACP), cytidine diphosphate-DAG (CDP-DAG). Figure 21-3 Major pathways of synthesis of fatty acids and glycerolipids in the green plant Arabidopsis. The major site of fatty acid synthesis is chloroplasts. Most is exported to the cytosol as oleic acid (18 1). After conversion to its coenzyme A derivative it is converted to phosphatidic acid (PA), diacylglycerol (DAG), and the phospholipids phosphatidylcholine (PC), phosphatidylinositol (PI), phosphatidylglycerol (PG), and phosphatidylethanolamine (PE). Desaturation also occurs, and some linoleic and linolenic acids are returned to the chloroplasts. See text also. From Sommerville and Browse.106 See also Figs. 21-4 and 21-5. Other abbreviations monogalactosyldiacylglycerol (MGD), digalactosyldiacylglycerol (DGD), sulfolipid (SL), glycerol 3-phosphate (G3P), lysophosphatidic acid (LPA), acyl carrier protein (ACP), cytidine diphosphate-DAG (CDP-DAG).
See other pages where Cytidine 5’-diphosphate CDP is mentioned: [Pg.87]    [Pg.1419]    [Pg.87]    [Pg.1419]    [Pg.96]    [Pg.431]    [Pg.806]    [Pg.630]    [Pg.18]    [Pg.867]    [Pg.90]    [Pg.239]    [Pg.83]    [Pg.5]    [Pg.78]    [Pg.89]    [Pg.566]    [Pg.69]    [Pg.101]    [Pg.93]    [Pg.190]    [Pg.132]    [Pg.201]    [Pg.211]    [Pg.19]    [Pg.85]    [Pg.294]    [Pg.361]    [Pg.120]    [Pg.276]    [Pg.277]    [Pg.1332]    [Pg.35]   
See also in sourсe #XX -- [ Pg.3 , Pg.223 , Pg.229 , Pg.230 ]



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