Cyclotetradecane derivatives

Group of maciocyclic diterpenes (unsaturated cyclotetradecane derivatives) found in tobacco, insects, soft corals (especially in the Great Barrier Reef), and pine trees. Activities against tumors and psoriasis have been reported. Cembrenene (C20H30, Mr 270.46, oil) exemplifies C. structures ... 

Cycloprotobuxine C, K36 Cyclosativene, T28 Cyclosteroids, T50-51 Cyclotetradecane derivatives, T41 Cycloundecanes, T30 Cyperene, T27 Cyperolone, T19 ep/-a-cyperone, T19 Cyperones, T20 Cyperotundone, T27 Cypridina luciferin, Y20 Cysteine, A4 Cystine, A4 Cytidine, 2 -deoxy, C4 Cytisine, K21 Cytochalasins, Y27... 

A similar situation occurred with the cyclotetradecanes. Subsequent to the isolation and identification of several hydroxy derivatives and epoxy derivatives of unsaturated cyclotetradecane from tobacco (3195, 3220, 3221, 3361) and smoke (3361), several trimethyl-(l-methylethyl)-substituted cyclotetradecatrienes and tetraenes were identified in tobacco (1149,1149a, 3853) and/or smoke (2726). 

Another novel system is presented in Figure 5.9 . This is a crystalline cubic phase formed with monoolein and Myverol . This structure was used to host [Ni (cyclam)] + or the derivative l-hexadecyl-1,4,8,111 tetraaza-cyclotetradecane. After obtaining a mixture of the lipids and the catalyst, the mixture was spread over a glassy carbon electrode or a thin mercury silver film. The best catalyst for the reaction was the substituted complex because the hydrophilic [Ni(cyclam)] + is easily removed from the cubic phase. The voltam-metric results indicate that the best response is obtained on the thin mercury film with formation of CO and regeneration of the catalyst. A further reaction of [Ni(cyclam)] + in the presence of CO generates [Ni(cyclam)CO]. 

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