2- -cyclopropanecarboxylic

A solution of the above ester (207.8 grams) and 64.5 grams of sodium hydroxide in 80 cc of water and 600 cc of ethanol is refluxed for 9 hours. The carboxylic acid of 2-phenyl-cyclopropane is liberated with 200 cc of concentrated hydrochloric acid. The 2-phenyl-cyclopropanecarboxylic acid contains 3 to 4 parts of the trans isomer to 1 part of the cis isomer. The acid is recrystallized from hot water. The pure trans isomer comes out as crystalline material (solid) while the cis isomer stays in solution. 

Cyclopentyl- 3-(N-piperidyl)ethyl ketone Cycrimlne HCI /3-Cyclopentyl propionic acid Testosterone 17/3-cypionate Cyclopentyl (tt-thienyl) hydroxy acetic acid Penthienate bromide Cyclopropanecarboxylic acid chloride Prazepam... 

Cyclopentenones reactions of 835, 836 synthesis of 620 Cyclopropanation 648 Cyclopropanecarboxylates, synthesis of 318 Cyclopropanes, synthesis of 772, 773, 785-787... 

Twenty-four grams (0.11 mole) of red mercuric oxide (Note 1) and 60 ml. of freshly distilled 1,1,2,2-tetrachloroethane are placed in a 250-ml. three-necked flask equipped with a dropping funnel, a reflux condenser, and a stirrer. A solution of 32.2 g. (0.20 mole) of bromine and 17.2 g. (0.20 mole) of cyclopropanecarboxylic acid in SO ml. of tetrachloroethane is added dropwise to the stirred suspension of mercuric oxide over a period of 45 minutes, the flask being kept in a water bath at 30-35° (Note 2). The mixture is stirred after the addition of the reactants until the evolution of carbon dioxide ceases. 

Bromocyclopropane has been prepared by the Hunsdiecker reaction by adding silver cyclopropanecarboxylate to bromine in dichlorodifluoromethane at —29° (53% yield) or in tetrachloro-ethane at —20° to —25° (15-20% yield).3 Decomposition of the peroxide of cyclopropanecarboxylic acid in the presence of carbon tetrabromide gave bromocyclopropane in 43% yield.4 An attempt to prepare the bromide via the von Braun reaction was unsuccessful.3... 

Bidret, 1 -PHENY L-2-THIO-, 42, 87 Brominadon, nuclear, aluminum chloride as catalyst for, 40, 7 of cyclopropanecarboxylic acid to bromocvclopropane, 43, 9 of phthalide using N-bromosuccin-imide, 42, 26... 

Cyclopentene-l,2-diol, 42, 51 2-Cyclopentene-1,4-dione, 42, 36 2-Cycloeentene-1-one, 42, 38 2-Cycloeentenone, 42,38 Cyclopropane, bromo-, 43, 9 Cyclopropanecarboxylic add, conversion to bromocyclopropane, 43, 9... 

The protocol is effective in preparation of hydrazides of 5 carbons or less. Cyclopropanecarboxylic acid hydrazide15 and isobutyric acid hydrazide16 were prepared from their corresponding acid chlorides in 64% and 71% yields, respectively. However, when this method was applied to cyclohexanecarboxylic acid chloride, the bis-acylhydrazide was the predominant product, and the mono-acylhydrazide17 was isolated in 25% yield.18... 

C4H5CIO 4023-34-1) see Buprenorphine Fexofenadine hydrochloride Naltrexone Prazepam cyclopropanecarboxylic acid ethyl ester (C(,H o02 4606-07-9) see Pimozide... 

In contrast to the synthesis of carbocyclic rings, the Cope rearrangement has been used sparsely for generating azepinones. Recently, the enantioselectivity of the conversion of 2-aza-divinylcyclopropane 286 has been investigated. The synthesis started from the optically active cyclopropanecarboxylic acid (90% ee), which had been converted into the isocyanate 286 by initial azidation to 285 and a consecutive Curtius rearrangement. Furthermore, the conditions of the iso-... 

GABAc receptors are defined by their insensitivity to bicuculline and their activation by conformationally restricted analogues of GABA such as CACA and (+)-CAMP (15, 2i -2-(aminomethyl)cyclopropanecarboxylic acid). They are blocked by picrotoxin but can be selectively antagonised by TPMPA (l,2,5,6-tetrahydropyridin4-ylphosphinic acid). Unlike GABAa receptors, they are not affected by benzodiazepines, barbiturates or anaesthetics (Barnard et al. 1998 Bormann 2000 Chebib and Johnston 2000). 

Schiller JG, AE Chung (1970) Mechanism of cyclopropane ring cleavage in cyclopropanecarboxylic acid. J Biol Chem 245 6553-6557. 

Cyfluthrin-met/ty/-fi(6 (provided in acetonitrile solution by Bayer Corp.) Cyfluthrin stable-isotope internal standard (IS), Cyclopropanecarboxylic acid, 3-(2,2-dichloroethenyl)-2,2-dimethyl-, cyano(4-fluoro-3-Phenoxyphenyl)methyl ester-met/tyWe, molecular formula C22H12D6CI2FNO3, molar mass 440.3, ion observed at 213.0 (GC/MS)... 

It is explosive, and distillation, even under reduced pressure as described, may be dangerous [1], A Hungarian patent describes a safe procedure for in-situ generation of the ester, azeotropic dehydration and subsequent metal-catalysed reaction with 1,3-dienes to give alkyl cyclopropanecarboxylates [2],... 

The solution is then cooled in an ice bath and acidified by 200 g. of concentrated sulfuric acid (sp. gr. 1.84) previously mixed with 300 g. of cracked ice. The solution is again cooled in an ice bath. The thick floating layer of cyclopropanecarboxylic acid and various polymers is separated and the cold aqueous solution extracted once with 1 1. of ether, using a stirrer instead of shaking (Note 5). The extract and crude acid are combined and dried over SO g. of Drierite, and the solvent is removed in a 500-ml. modified Claisen flask2 on a steam bath. The residue is then distilled under reduced pressure. The yield of acid boiling at 94-95°/26 mm. or 117—118°/75 mm. is 63.5-68 g. (74-79%) (Note 6). 

Cyclopropanecarboxylic acid has been prepared by the hydrolysis of cyclopropyl cyanide,3 although it is unnecessary to... 

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