Process of Producing Cyclopropanecarboxylate Compounds

Furukawa etal, US Patent 6,414,181 (July 2, 2002) Assignee Sumitomo Chemical Company, Limited Utility Pyrethroid Precursor 

t-Butyl (+/—)-trans-2,2-dimethyl-3-2-carboxy-(E)-l-propenylcyclopropane carboxylate 

At ambient temperature, 100 ml dimethyl ether was added to the product from Step 1 and the solution washed with 3 M HCl and brine. The organic layer was isolated, dried, removed under reduced pressure, the product purified using chromatography on silica with n-hexane/EtOAc, 3 1, and isolated in 96% yield. H-NMR data supplied. 

Amine Vol (ml) Solvent Reaction Temp. (°C) Reaction Time (hr) Yield (%) 

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