Diazepam Cyclophosphamide

Amitriptyline, barbiturates, chlorproguanil, citalopram, clomipramine, clozapine, cyclophosphamide, diazepam, hexobarbital, imipramine, pentamidine, phenobarbital, phenytoin, propranolol, quinine, (S)- and (Jf)-warfarin, zidovudine... 

Safety Commission Consumer Products Copper (Cu) Corrosives Corticosteroids Cosmetics and Personal Care Products Cotinine Coumarins Creosote Cresols Cromolyn Cumene Cumulative Risk Assessment Cyanamide Cyanide Cyanogen Chloride Cyclodienes Cyclohexamide Cyclohexane Cyclohexene Cyclophosphamide Cyclosporine Cyfluthrin Cypermethrin Cysteine Cytochrome P-450 "2,4-D (2,4-Dichlorophenoxy Acetic Acid)" Limonene Dalapon DDT/DDE/DDD Decane DEBT (Diethyltoluamide) DEE Deferoxamine DEHP (Di-Ethyl Hexyl Phthalate) Delaney Clause Deltamethrin Deodorants Detergent Developmental Toxicology Dextromethorphan Diazepam Diazinon Diazoxide Dibenzofuran " Dib enz [a, h] anthracene" Dibromochloropropane Dibutyl phthalate Dicamba Dichlone Dichlorobenzene Dichloroethanes "Dichloroethylene, 1,1-"... 

Proton pnmp inhibitors Omeprazole Lansoprazole Pantoprazole Antiepileptics Diazepam Phenytoin Phenobarbitone Amitriptyline Clomipramine Cyclophosphamide Progesterone... 

Atrazine, bupropion, cyclophosphamide, dextromethorphan, dextromethorphan, diazepam, dibenzo[a,h]anthracene, halothane, lidocaine, (S)-mephenytoin, (S)- and (i )-mianserin, nicotine, testosterone... 

Acetaminophen, aldrin, alfentanil, amiodarone, aminopyrine, amitriptyline, amprenavir, androstenedione,antipyrine, astemizole, benzphetamine, budesonide, carbamazepine, celecoxib, chlorpromazine, chlorzoxazone, cisapride, clarithromycin, clozapine, cocaine, codeine, cortisol, cyclophosphamide,cyclosporin, dapsone, delavirdine, dextromethorphan, digitoxin, diltiazem, diazepam, erythromycin, 17j3-estradiol, ethinylestradiol, etoposide, felbamate, fentanyl, flutamide, hydroxyarginine, ifosphamide, imipramine, indinavir, ketoconazole, lansoprazole, loratidine, losartan, lovastatin, (iS)"mephen3d in, methadone, mianserin, miconazole, mifepristone, nelfinavir, nevirapine, nicardipine, nifedipine, odansetron, omeprazole, orphenadrine, proguanil, propafenone, quinidine, quinine, rapamycin, retinoic acid, ritonavir, saquinavir, selegiline, serindole, sufentanil, sulfinpyrazone, tacrolimus, tamoxifen, tamsulosin, taxol, teniposide, terfenadine, tetrahydrocannabinol, theophylline, toremifene, triazolam, trimethadone, trimethoprim, troleandomycin, verapamil, warfarin, zatosetron, Zolpidem, zonisamide... 

Delon, A. Favreliere, S. Couet, W. Courtois, P. Bouquet, S. Rapid and sensitive determination of thalidomide in human plasma hy high-performance liquid chromatography. J.Liq.Chromatogr., 1996, 18, 297—309 [SPE ciprofloxacin is IS simultaneous acyclovir, azathioprine, cefotaxime, ceftazidime, flucytosine, metronidazole non-interfering amphotericin, clobazam, clonazepam, cyclophosphamide, cyclosporin, diazepam, diltiazem, hydro zine, nifedipine, prednisolone]... 

Animal studies suggest that the benzodiazepines may possibly increase the metabolic activation and the toxicity of high doses of cyclophosphamide and ifosfamide. However, diazepam did not alter the pharmacokinetics of high-dose cyclophosphamide in a clinical study. Note also that lorazepam is widely used for chemotherapy-induced nausea and vomiting. 

Sasaki K-I, Furusawa S, Takayanagi G. Effects of chlordiazepoxide, diazepam and oxazepam on the antitumour activity, the lethality and the blood level of active metabolites of cyclophosphamide and cyclophosphamide oxidase activity in mice. JPharmacobioi n (1983) 6, 161-72. 

A 43-year-old woman with breast cancer and no history of seizures was scheduled to undergo chemotherapy with cyclophosphamide, 5-fluorouracil, and epirubicin and to receive antiemetic treatment with intravenous dexamethasone 8 mg and palonosetron 0.25 mg. During the fourth cycle of chemotherapy, she developed a generalized tonic-clonic seizure, which lasted 8 minutes and was followed by a period of drowsiness. She was given intravenous diazepam 10 mg and a saline infusion. Detailed investigations, including brain CT scan, did not reveal abnormalities, and she recovered completely. 

Noninterfering amitriptyline, carbamazepine, carmustine, chlorpromazine, cimeti-dine, cisplatin, cyclophosphamide, dexamethasone, diazepam, digoxin, etoposide, furo-semide, haloperidol, ibuprofen, imipramine, indomethacin, methotrexate, phenobarbi-tal, phen3doin, propranolol, ranitidine, theophylline, triazolam, warfarin... 

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