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Cyclooxygenase reaction products thromboxanes

Classically, inflammation is a protective reaction of the body in response to some physical, chemical, or microbial injury and insult of the cells. Acute inflammation, rapid onset and shorter duration, is considered as a healthy response. However, when inflammation continues for prolonged period of time, it becomes detrimental and may raise the first step of a chronic disease (Medzhitov, 2008). Arachidonic acid/COX and nuclear factor- (NF- ) are well known inflammatory pathways which induce production of inflammatory mediators such as prostaglandins, thromboxanes, leukotrienes, and cytokines. Most commonly accepted mechanism of anti-inflammation is inhibition of cyclooxygenase (COX) activity. There are two kinds of cyclooxygenases COX-1 is natural protective enzyme of intestinal mucosa while COX-2 is induced by tissue damage as an inflammatory mediator (Maroon et al., 2006). NF- is a recently identified... [Pg.141]

Cyclooxygenase pathway All eicosanoids with ring structures, that is, the prostaglandins, thromboxanes, and prostacyclins, are synthesized via the cyclooxygenase pathway. Two cyclooxygenases have been identified COX-1 and COX-2. The former is ubiquitous and constitutive, whereas the latter is induced in response to inflammatory stimuli. The products of these and subsequent reactions in this pathway are summarized in Figure 39.3. [Pg.413]

The finding that the endoperoxides caused platelet aggregation made it of interest to study the transformations of arachidonic acid in suspensions of human platelets. Two pathways were identified [16]. The initial reaction of one of them was catalyzed by fatty acid cyclooxygenase and led to the formation of three major end-products, i.e. 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT), malondialdehyde, and a novel hemiacetal derivative named thromboxane 82 (TXBj). The other pathway consisted of conversion of arachidonic acid into 12L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) by a novel lipoxygenase. The hydroperoxide was subsequently converted into a stable end-product, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) by a glutathione peroxidase [16,17]. [Pg.46]


See other pages where Cyclooxygenase reaction products thromboxanes is mentioned: [Pg.1001]    [Pg.1001]    [Pg.235]    [Pg.182]    [Pg.81]    [Pg.332]    [Pg.175]    [Pg.305]    [Pg.127]    [Pg.283]    [Pg.110]    [Pg.222]   
See also in sourсe #XX -- [ Pg.341 , Pg.342 ]




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Cyclooxygenase

Cyclooxygenase 2 production

Cyclooxygenase products

Cyclooxygenase reaction

Cyclooxygenase reaction products

Thromboxan

Thromboxane Thromboxanes

Thromboxanes

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