Cyclooxygenase-2 inhibitors cardiovascular effects

J. M. Brophy, Cardiovascular effects of cyclooxygenase-2 inhibitors, Curr. Opin. Gastroenterol., 2007, 23, 617-624. 

Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. Am] Ther. 2004 11 244-250. 

Aspirin produces an antipyretic and anti-inflammatory effect primarily by irreversibly inhibiting cyclooxygenase (thus having similar effects to NSAIDs). It possesses an antiplatelet effect that may have additive effect with other drugs with a similar effect (e.g, selective serotonin reuptake inhibitors) and those which affect other aspects of blood clotting. The risk of interactions and adverse effects are reduced by using a lower dose (e.g. 75 mg) fortunately, a full antiplatelet effect is seen at this dose. This is considered in Part 1, Cardiovascular Drugs. 

Johnson, A J., Hsu, Ai., Song, X., Lin, H.P., and Chen, C.S. (2002) The Cyclooxygenase-2 Inhibitor Celecoxib Perturbs Intracellular Calcium by Inhibiting Endoplasmic Reticulum Ca -ATPases. A Plausible Link with Its Antitumor Effect and Cardiovascular Risks, Biochem J. 366 (Pt 3), 831 37. 

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