Cyclooxygenase inhibitor aspirin

Recently, nitroderivatives of aspirin and RGBS peptide have been synthesised in order to capitalise on the synergy of NO with cyclooxygenase inhibitors (aspirin) and the... 

Cyclooxygenase inhibitors Aspirin Ibuprofen, celecoxib, etc (see Chapter 36) ... 

Unlike aspirin and other cyclooxygenase inhibitors that work on the COX-1 and COX-2 enzymes, acetaminophen works on the COX-3 enzyme, which is present in the spinal column and brain. This helps it to avoid shutting down prostaglandin function elsewhere in the body, which is why it has no anti-inflammatory effects and does not affect blood platelets or the stomach lining. 

Like aspirin, ibuprofen is a nonsteroidal anti-inflammatory drug. It is a cyclooxygenase inhibitor that interferes with COX-1 and COX-2 forms of that enzyme. Its effects on COX-2 give it fever-reducing (antipyretic), analgesic (pain relief), and anti-inflammatory functions. 

The widely used platelet inhibitor aspirin or acetylsalicylic acid, by acetylating the enzyme cyclooxygenase, inhibits platelet function by preventing the formation of thromboxane A2 and the synthesis of prostaglandin I2 (PGI2) (68). Aspirin has been used in combination with other antiplatelet agents such as ticlopidine, which inhibits ADP-induced platelet aggregation (69). 

The answer is d. (Katzung, p 605.) Celocoxib is a eyelooxygenasell inhibitor. Aspirin, ibuprofen, and piroxicam are relatively no ns elective inhibitors of cyclooxygenases. Acetaminophen has no effect on cyclooxygenases. 

NSAiDs (nonsteroidai anti-infiammatory drugs) inhibitors of cyclooxygenase, including aspirin, ibuprofen, and ketoprofen, among many others. 

Far out the most important agent in this group is aspirin, a cyclooxygenase inhibitor which is discussed in more detail in Chapter 26. Its unique properties as a platelet aggregation inhibitor are brought forward by the fact that while platelet cyclooxygenase is irreversibly inhibited at low doses of aspirin the synthesis in endothelium of prostacyclin, a platelet aggregation inhibitor itself, recovers more quickly. 

Additive - the drugs have the same biochemical mechanism and will react with the target cells as long as receptor sites are available. Examples are the cyclooxygenase inhibitors (prostaglandin synthesis inhibitors) aspirin and acetaminophen (Tylenol ), antihypertensives propanolol and the rauwolfia alkaloids. 

In contrast to aspirin, however, they are not cyclooxygenase inhibitors and have no antiinflammatory properties. Clinically, acetaminophen is preferred over phenacetin, because it has less overall toxicity. 

Wu KK. Aspirin and other cyclooxygenase inhibitors new therapeutic insights. Semin Vase Med. 2003 3 107-112. 

Aspirin, cyclooxygenase, and the provocation of asthma A few people with asthma suffer from a unique syndrome in which the ingestion of 40 to 300 mg of aspirin produces rhinorrhea and acute bronchoconstriction. All cyclooxygenase inhibitors will precipitate bronchospasm in patients with aspirin-evoked asthma. 

Catella-Lawson F Reilly MR Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 2001 345 1809-1817. 

Extoisive experimental studies with these inhibitois have been perfomied in vitro and in vivo, and a limited number of clinical trials have been carried out As yet none of these agents have a defined role in clinical medicine. Although they have several theoretical advantages over cyclooxygenase inhibitors (203,204), definite superiority of these agents over aspirin in human therapy remains to be demonstrated (205). 

Benoral benorylate. benorilate benorylate. benorylate [ban] (benorilate [inn] paracetamol acetylsallcylate BenoraP ) is an aspirin-paracetamol ester, and these two pharmacologically active constituents are released systemically at different rates. It has cyclooxygenase inhibitor, nsaid analgesic, antiinflammatory and antirheumatic activity. It is used orally, particularly to treat the pain of rheumatic disease and other musculoskeletal disorders, as well as to treat fever, benoxaprofen [ban, inn, usan] (Opren ) is one of the propionic acid series of CYCLOOXYGENASE INHIBITORS with nsaid ANALGESIC. ANTIINFLAMMATORY and ANTIPYRETIC activity also effective for psoriasis. It was withdrawn due to adverse drug reactions. 

---