Cyclodextrins effects

Structurally developed cyclodextrins. Effective procedures for the selective functionalization of peripheral hydroxyl groups on the cyclodextrins have been developed. A motivation for these studies has been to produce suitably functionalized hosts which will induce enhanced reaction rates... 

Agu, R. U., Jorissen, M., Willems, T., Van Den Mooter, G., Kinget, R., Verbeke, N., and Augustijns, R (2000), Safety assesment of selected cyclodextrins Effect on ciliary activity using a human cell suspension model exhibiting in vitro ciliogenesis, Int. J. Pharm., 193, 219-226. 

Hatzi P, Mourtas SG, Klepetsanis P, Antimisiaris SG (2007) Integrity of liposomes in presence of cyclodextrins Effect of Kpo-some type and lipid composition. Int J Pharm 333 167-176... 

Y. Sueishi and T. Nishimura, Complexation of spiropyrans with cyclodextrins Effects of p- and y-cyclodextrins on the thermal isomerization of 6-S03-spiropyran, J. Phys. Org. Chem. 8, 335-340(1995). 

Orienti, 1., Zecchi, V., Bettasi, V., Eini, A. Release of ketoprofen from dermal bases in presence of cyclodextrins effect of the affinity constant determined in semisolid vehicles. Arch. Pharm. (Weinheim) 1991,324, 943-947. 

Scalia S, Mohnari A, Casolari A, Maldotti A. 2004. Complexation of the sunscreen agent, phenyl-benzimidazole sulphonic acid with cyclodextrins Effect on stability and photo-induced free radical formation. European Journal of Pharmaceutical Sciences 22(4) 241-249. 

Scheme 32 Study of cyclodextrins effect on the synthesis of W-acetyllactosamine derivative 21 by /31,4-galactosyltransferase.

Fava F, Di Gioia D, Marchetti L. (1998). Cyclodextrin effects on the ex-situ bioremediation of a chronically polychorobiphenyl-contaminated soil. Biotechnology and Bioengineering 58 345-355. 

We also examined Diels-Alder reactions in a cyclodextrin complex. In the reaction of cyclopentadiene with 2-butenone (Figure 2.3) or with acrylonitrile we saw that there was catalysis in water with j8-cyclodextrin, but not with a-cyclodextrin, which was an inhibitor. The cyclopentadiene bound into both of the cyclodextrins, but only in the j3-cyclodextrin is there also room for the dienophile to fit. In this same publication we saw that the Diels-Alder reaction is also strongly accelerated simply in water solution, which favours the transition state for the reaction in which a smaller total amount of hydrophobic surface is exposed to the water solvent. This latter finding stimulated us, and others, to study many other examples of catalytic effects in water alone with hydrophobic reagents. However, the cyclodextrin effect was added on top of this in the case where both reagents could fit into the pocket. 

M. Osaki, Y. Takashima, H. Yamaguchi, A. Harada, Polymerization of lactones initiated by cyclodextrins effects of cyclodextrins on the initiation and propagation reactions. Macromolecules, 2007, 40, 3154-3158. 

Cevallos, R A. R, Buera, M. R, and Elizalde, B. E. (2010). Encapsulation of cinnamon and thyme essential oils componenk (cinnamaldehyde and thymol) in P-cyclodextrin Effect of interactions with water on complex stability. Journal of Food Engineering, 99, 70-75. 

Veglia, A. V. and de Rossi, R. H., Beta-cyclodextrin effects on the photo-Fries rearrangement of aromatic alkyl esters, /. Org. Chem., 58,4941, 1993. 

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