4- cyanophenyl-4 - synthesis

The synthesis of the mesogenic trans-4-n-alkyl-(4 -cyanophenyl)-cyclohexanes (PCHn) was described by Eidenschink et al. [65] in 1977. Most of the compounds exhibit a nematic phase close to room temperature. The chemical structure of the mesogenic PCHn is shown in Fig. 6. During the past few years, the crystal structures of some mesogenic phenylcyclohexanes were published [66-70]. Selected crystallographic and molecular data of the investigated compounds PCHn are presented in Table 4. 

A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamines and thieno[3,2-d]pyridin-4-ylamines based on the condensation of appropriately functionalized N -(2-cyanophenyl)-N,N-dimethylformamidines and primary amines has been reported by Han and coworkers (Scheme 6.253) [440]. Optimization of the reaction parameters resulted in the use of acetonitrile/acetic acid as a solvent mixture and of 1.2 equivalents of the requisite amine. In general, microwave heating at 160 °C for 10 min provided excellent product yields. 

D. Horton, Y. Li, V. Barberousse, F. Bellamy, P. Renant, and S. Samreth, Synthesis of the 2- and the 4-monomethyl ethers and the 4-deoxy-4-fluoro derivative of cyanophenyl l.S-dithio-p-D-xylopyranoside as potential antithrombic agents, Carbokydr. Res. 249 39 (1993). 

A further extension of this type of synthetic sequence is illustrated by the cyclization of 2-cyanoethyl(o-cyanophenyl)-phenylphosphine to the corresponding o-enaminenitrile followed by hydrolysis with acid to form 2,3-dihydro-l-phenyl-4(lH)-phosphinolinone.8 The only other reported synthesis of this... 

A different synthetic procedure to introduce cyanophenyl groups at the apical position (12c) was reported by Kobayashi et al. in 2004, together with the synthesis of the two new tetradentate cavitand ligands 14 and IS (Figure 7.4) [26]. 

The reaction of (2-cyanophenyl)azo phenyl sulphide or r-butyl sulphide with PhCT ions in DMSO followed by lactonization is another route to the synthesis of these compounds349. 

Azobenzene2 or l,2-di(4 -pyridyl)etheneI was used as a reduction catalyst. The generated benzenetellurolate was employed in the synthesis of cyanophenyl phenyl tellurium compounds1 and of benzoylphenyl phenyl tellurium compounds2. 

Bozo, E, Boros, S, Kuszmann, J, Synthesis of 4-cyanophenyl 2-azido-2-deoxy- and 3-azido-3-deoxy-1,5-dithio-p-D-xylopyranosides, Carbohydr. Res., 301, 23-32, 1997. 

A novel synthesis of a fused isoxazole is based on the cyclization of the 0-(o-cyanophenyl)oxime of acetone in an acidic medium and at ambient temperature. 

N4-diamide alkyl-substituted, 141 dimer, synthesis of, 142 dimethyl-substituted, 141 p-cyanophenyl-substituted, 141 synthesis of 141... 

Brief accounts of the synthesis of trans-4-alkylcyclohexane carboxylic acids > and their para-cyanophenyl esters > have already appeared. This paper details a convenient synthesis of the parent nematogenic acids and reports on some of their para-alkylphenyl esters as well as those of Demus et al. ... 

The Synthesis of 7-(4-Cyanophenyl)-3-(dibutylaiiiino)benzofuro [2,3-c]-oxazolo[4,5-aJcarbazole (38a) and 7-(4-Cyanopbenyl)-3-(dibutylamino) benzofuro[23-c]oxazolo[5,4-a]carbazoIe (39a) ... 

C. Synthesis of m- m-Phenoxyalkoxy)henzamidines 4, 5, H6). The preparation of substituted TO-phenoxyalkoxybenzamidines follows a general scheme in which an ,a)-dihaloalkane 86) in large excess is used to monoalkylate m-cyanophenol 34). The resulting a-bromo-ia-(3-cyano-phenyl) alkane 36) is alkylated with an excess of phenol (37) to give an a-phenyl- -(3-cyanophenyl) alkane 38), which is converted to the m-substituted benzamidine 34-36) by the Pinner reaction. When n. = 3, the synthesis is as follows. To 20 mmoles of m-cyanophenol 36) in 10 ml... 

H. Synthesis of m-Styrylbemamidine p-Toluenesvlfonate 31) and m-Phenylethylbenzamidine p-Toluenesulfonate 82). By a procedure similar to that for compound 52, equal molar amounts of m-cyanobenzyl-triphenylphosphonium bromide 50) and benzaldehyde 54) are allowed to react with a slight excess of sodium methoxide in methanol. The resulting 2-(3-cyanophenyl) styrene is used directly in the Pinner reaction to yield compound 31. 

Bromoadenosine monophosphate, 99 3-Bromo-2-butanone-l,4-diol diethyl ketal, synthesis of, 393, 394 Bromocolchicine, 567-571 binding to brain extracts, 570,571 synthesis of, 569 Bromoconduritol, 369,370 inhibition of glucosidase, 381 synthesis of, 380, 381 a-Bromo-ft>-(3-cyanophenyl)alkane, 122 6-Bromo-6-deo conduritol B epoxide, active site labeling, 377-380 3-Bromo-l,4-dihydroxy-2-butanone 1,4-bisphosphate, 142, 392, 396, 397 synthesis of, 392-395... 

F. (2004) Synthesis of the enantiomers and N-protected derivatives of 3-amino-3-(4-cyanophenyl)propanoic acid. Tetrahedron Asymmetry, 15, 1893-1897. 

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