CXC receptors

Manna SK, Sarkai A, Sreenivasan Y (2006) Alpha-melanocyte-sdmuladng hormone down-regulates CXC receptors dirough aedvation of neudophil elastase. Eur J Immunol 36 754—769... 

Chemokines exert their action through seven-transmembrane receptors, which are GPCRs (Fig. 4.2). Six CXC receptors, 10 CC receptors, and one receptor each for lymphotactin and fractalkine have been identified. Table 4.1 summarizes the human chemokine receptor family, their ligand specificity, and the cell types that predominantly express these receptors. The new nomenclature for chemokines is also included in the table (8). 

Renzoni E, Lympany P, Sestini P, Pantelidis P, Wells A, Black C, Welsh K, Brunn C, Knight C, Foley P, du Bois RM (2000) Distribution of novel polymorphisms of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and cryptogenic fibrosing alveolitis. Arthritis Rheum, 43 1633-1640. 

Dunican A, Grutkoski P, Leuenroth S, Ayala A, Simms HH Neutrophil regulate their own apoptosis via preservation of CXC receptors. J Surg Res 2000 90 32-38. 

Planaguma, A., Domenech, T., Pont, M., Calama, E., Garcia-Gonzalez, V., Lopez, R., et al. (2015). Combined anti CXC receptors 1 and 2 therapy is a promising antiinflammatory treatment for respiratory diseases by reducing neutrophil migration and activation. Pulmonary Pharmacology Therapeutics, 34, 37—45. http //dx.doi.org/ 10.1016/j.pupt.2015.08.002. 

Zernecke, A. et al. (2008) Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circulation Research, 102, 209-217. 

Although most chemokines recognize more than one receptor, it seems to be a general rule that CC receptors only bind CC chemokines, whereas CXC chemokines are recognized by CXC receptors. Thus there is no crossreactivity between members of the four chemokine subfamilies [8j. However, exceptions to this rule have been published [12-15]. 

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