Current Trends for APCI

Although APCI began as a tool for analysis of VOCs in air, it is now more commonly used as the ionization source iu mai mass spectrometry (MS) techiuques. This is beeause the APCI source eanbe simply adapted for direct coupling of separation techniques to the mass spectrometer. Although the emphasis iu tins ehapter is ou air samples, there has been widespread integration of APCI into LC-MS where a heated nebulizer vaporizes the LC solvent and ereates the reagent ions from the 

The reactant ions spectram generated from an APCI source is therefore dominated by solvent-derived cluster ions [13]. 

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