Curcumin antitumor activity

The in vitro antitumor activity of curcumin in HPV-associated cells has been established [Roy et al., 2002]. Curcumin modulates the in vitro expression and function of Pgp in multidrug-resistant human KB-V1 cells [Anand et al., 2008 Chearwae et al., 2004] and sensitizes cisplatin-resistant SiHa cells to cisplatin-induced apoptosis [Venkatraman et al., 2005], indicating its ability to reverse MDR in cervical cancer cells. The effect of curcumin in HPV-associated cells was found to involve the down-regulation of viral oncogenes, NF-kB and AP-1 [Anand et al., 2008 Divya and Pillai, 2006],... 

We demonstrated that a naturally derived polysaccharide, chitosan, is capable of forming composite nanoparticles with silica. For encapsulated particles, we used silicification and biosilicification to encapsulate curcumin and analyzed the physicochemical properties of curcumin nanoparticles. It proved that encapsulated curcumin nanoparticles enhanced stability toward ultraviolet (UV) irradiation, antioxidation and antitumor activity, enhanced/added function, solubility, bioactivities/ bioavailability, and control release and overcame the immunobarrier. We present an in vitro study that examined the cytotoxicity of amorphous and composite silica nanoparticles to different cell lines. These bioactives include curcumin mdAntrodia cinnamomea. It is hoped that by examining the response of multiple cell lines to silica nanoparticles more basic information regarding the cytotoxicity as well as potential functions of silica in future oncological applications could become available. 

Curcuma longa L. C. domestica L. Yu Jin (Turmeric) (tuber) 1-curcamene, sesquiterpene, camphor, camphene, curmarin, curzernone, curzenene, curcumol, furanodienone, furanodiene, zederone, curcolone, diol, procurcumenol, curdione, curcumin. 33-398-460-510 Anti-inflammatory, antitumor, anti-infectious properties, antioxidative activity. Activate blood flow, remove blood stasis. 

Pervaiz, S. (1 990) Antitumor and antiviral activity of curcumin and light. Proceedings of the Annual Meeting of the American Association of Cancer Research Abstract A2325. 

The major pigment in Curcuma species (Zingiberaceae family) is the yellow phenolic diarylheptanoid curcumin (Jl). Curcumin and its analogs have potent antioxidant and antiinflammatory effects, cytotoxicity against tumor cells, and antitumor-promoting activity (96). The biologic effects and targets of curcumin, as well as its possible roles in cancer prevention and therapy, have been reviewed recently (97, 98). 

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