Curcumin analogs structures

Dinkova-Kostova AT, Talalay P. 1999. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis 20 911-914. 

Recently, Youssef et al. [24] reported the synthesis of curcumin analogs as potential antioxidant and cancer chemopreventive agents. The general structures of the synthesized analogs are shown in Fig. (8). These compounds were tested for scavenging ability of DPPH free radicals and in an ATP chemiluminescence assay. The SAR conclusions from the results were mainly consistent with the prior conclusions drawn by other researchers. In addition, they found that di-substitution of the central methylene group resulted in decreased antioxidative activity. 

Fig. (8). General structures of curcumin analogs synthesized by Youssef et al. [24]...

Table 5. Structures of curcumin analogs and anti-HIV-1 integrase ability [39]...

In order to search for new chemopreventive enzyme inducers and to elucidate the structural features responsible for the ability of curcumin to induce Phase 2 detoxification enzymes, Dinkova-Kostova et al.[48, 49] examined some natural as well as synthetic curcumin analogs for ability to induce NAD(P)H quinone reductase (a prototype for phase 2 detoxification enzymes) in murine hepatoma cells. Compounds... 

Fig. (11). Structures of curcumin analogs and their inducer potencies (CD/pM) in the QR assay in Hepa lc lc7 murine hepatoma cells [48] (CD value is the concentration required to double the quinone reductase specific activity.)...

Lin L, Lee KH. Structure-activity relationships of curcumin and its analogs with different biological activities. In Studies in Natural Products Chemistry, Volume 33. Ur-Rahman A, ed. Elsevier, New York, pp. 785-812. 

STRUCTURE-ACTIVITY RELATIONSHIPS OF CURCUMIN AND ITS ANALOGS WITH DIFFERENT BIOLOGICAL ACTIVITIES1... 

Curcumin exhibits diverse biological activities and has numerous biological targets [2]. Various research groups have studied the SAR of curcumin and its analogs with respect to different activities. In this part of the review, the relationships between the structures of curcumin and its analogs and their targeted activities will be discussed and summarized. 

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