Cunninghamella bainieri

Eerris JP, EH MacDonald, MA Patrie, MAMartin (1976) Aryl hydrocarbon hydroxylase activity in the fungus Cunninghamella bainieri evidence for the presence of cytochrome P-450. Arch Biochem Biophys 175 443-452. 

Acronycine 0 0CH3 Cunninghamella echinulata NRRL 3655 Cunninghamella bainieri ATCC 9244 Aromatic hydroxylation [25]... 

Ferris, J. P., Fasco, M. J-, Stylianopoulou, F. L, Jerina, D. M., Daly, J. W. Jeffrey, A. M. (1973). Mono-oxygenase activity in Cunninghamella bainieri Evidence for a fungal system similar to liver microsomes. Archives of Biochemistry and Biophysics, 156, 97-103-... 

Apart from mammalian tissue preparations, microbial systems also appear to be active in the metabolic conversion of arylalkylamines to oximes. Thus, incubation broths of the fungus Cunninghamella bainieri supplemented with amphetamine have been detected to contain phenylacetone oxime (28) as one of the major metabolites36. 

Cunninghamella bainieri ATCC 3065 Streptomyces punipalus NRRL 3529... 

Single or Multiple Pathways Modeling A single microbial model (one culture) may exhibit the entire complex of divergent routes of mammalian metabolism seen with a particular substrate in numerous mammalian species. For example, Cunninghamella bainieri was shown to produce several known oxidative mammalian metabolites of N-n-propylamphetamine. Alternatively, one culture may exhibit a single route of metabolism in lieu of all others. This is particularly useful if the pathway is minor and/or quantitatively masked by other routes of metabolism in mammals, and thus hard to study. In this case, the ultimate "microbial model" may be a composite of cultures, each exhibiting the individual reactions. 

Fungi Cunninghamella bainieri Microsomes Xenobiotics Alcohol, phenols epoxides 29)... 

Ata and Nachtigall (2004) reported that a-santonin (190) was incubated with Rhizopus stolonifer to give (187a) and (183b), while with Cunninghamella bainieri, C. echinulata, and M. plumbeus to afford the known 1,2-dihydro-a-santonin (187) (Figure 20.62). 

FIGURE 20.62 Biotransformation of a-santonin (190) by Rhizopus stolonifer, Cunninghamella bainieri, Cunninghamella echinulata, and Mucorplumbeus. 

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