Cumulative inhibition

Aspirin has been remarkably successful in the treatment of the pain and swelling of inflammatory disease and in fact, an estimated 45,000 tons of aspirin are still consumed each year. This success resulted in the syntheses of many other aspirin-like drugs , now referred to as NSAIDs. Aspirin, however, continues to have a unique use in the prevention of thrombosis. Since it produces irreversible inhibition of COX-1 by acetylation of serine at position 530 in the active site, a daily low dose of aspirin will cause a cumulative inhibition of COX-1 in platelets, in the portal circulation. A gradual inhibition of platelet aggregation occurs, reducing the possibility of occlusion of coronary or cerebral vessels by platelet thrombi. However, there are no systemic... 

ISOTOPE EXCHANGE AT EQUILIBRIUM WEDLER-BOYER TECHNIQUE CUMULATIVE INHIBITION UNCONSUMED SUBSTRATE CRYPTIC CATALYSIS BOROHYDRIDE REDUCTION ENZYME CASCADE KINETICS... 

Patrignani P, Filabozzi P, Patrono C Selective, cumulative inhibition of plate-let thromboxane production by low-dose aspirin in healthy subjects. J. Clin. Invest 2-1366,1982... 

Because of its rapid biotransformation, methomyl does not tend to cause cumulative toxicity. However, repeated, frequent exposures could lead to cumulative inhibition of cholinesterase, resulting in flu-like symptoms including weakness, loss of appetite, and myalgia. 

Potential Physiological Significance for Nicotinoid-prodncing Plants Themselves. Nicotine, nomicotine, anabasine, and anatabine were shown to produce a cumulative inhibition of the invertase activity of Nicotiana glauca. The alkaloids may have a role in the functional behaviour of this enzyme which cleaves... 

In a third example case, p-carbolines are inhibitors of monoamine oxidases (MAO-A and MAO-B) and can be found in foods, hallucinogenic plants or certain plant dmgs. The referred article described a fast analysis method for p-carbolines based on the inhibition of MAO [79]. The MAO-A is inhibited by all three tested P-carbolines (harmane, norharmane and harmaline), while MAO-B is inhibited only by norharmane. The presence of norharmane in mixtures of p-carbolines can be identified based on the difference between the cumulative inhibition of MAO-A by all p-carbolines and MAO-B inhibition. The enzymes were immobilized on screen-printed electrodes modified with a stabilized film of Pmssian blue that contain also copper. Benzylamine was used as substrate for the enzymatic reaction and the hydrogen peroxide formed was measured amperometrically at —50 mV. The developed biosensors were used for food analysis. The detection limits obtained were 5.0 pM for harmane and 2.5 pM for both harmaline and norharmane. 

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